Steroids

Using real-world data to inform dosing strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study.

Rituximab is frequently used off-label for the treatment of frequent-relapsing/steroid-dependent nephrotic syndrome (FRNS/SDNS). However, the optimal dosing schedules remain undetermined. The objective of this study was to establish a population pharmacokinetic-pharmacodynamic (PK-PD) model in pediatric patients with FRNS/SDNS, and to investigate dosing regimens that provide adequate suppression ...

Identification of mitophagy-related biomarkers in human osteoporosis based on a machine learning model.

Osteoporosis (OP) is a chronic bone metabolic disease and a serious global public health problem. Several studies have shown that mitophagy plays an important role in bone metabolism disorders; however, its role in osteoporosis remains unclear. The Gene Expression Omnibus (GEO) database was used to download GSE56815, a dataset containing low and high BMD, and differentially expressed genes (DEGs...

Adrenal incidentalomas, cortisol secretion and cancer: is there a real crosstalk?

BACKGROUND: Cortisol has immunomodulatory effects that increase the risk and evolution of several diseases. Cancer is characterized by a proinflammato...

Evaluation of deep learning-based quantitative computed tomography for opportunistic osteoporosis screening.

To evaluate diagnostic efficacy of deep learning (DL)-based automated bone mineral density (BMD) measurement for opportunistic screening of osteoporos...

Effects of exogenous energy on synthesis of steroid hormones and expression characteristics of the CREB/StAR signaling pathway in theca cells of laying hen.

Energy and the cAMP-response element binding protein (CREB)/steroidogenic acute regulatory protein (StAR) signaling pathway play important roles in st...

Causal factors in childhood and adolescence leading to anabolic-androgenic steroid use: A machine learning approach.

BACKGROUND: Prior research has demonstrated associations between anabolic-androgenic steroid (AAS) use and features from several childhood and adolesc...

Comparative Evaluation of Caudal Epidural Method to Ultrasound-Guided S1 Transforamen Block in Patient's Lumbar Discectomy with Failed Back Syndrome Symptoms: A Double-Blind Clinical Trial.

BACKGROUND: Post-lumbar surgery syndrome (PLSS) refers to persistent or recurrent pain following spinal surgery with an unknown cause. It is commonly ...

A Cohort Study Investigating Zearalenone Concentrations and Selected Steroid Levels in Patients with Sigmoid Colorectal Cancer or Colorectal Cancer.

THE AIM: In this study was to determine if sigmoid colorectal cancer (SCC) and colorectal cancer (CRC) in women (W) and men (M) is accompanied by zear...

Psychological Alterations in Youths with Type I Diabetes: Associations with Salivary Cortisol Concentration.

Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children and adolescents, and is associated with stress and other psych...

Asprosin is a Reliable Predictor of Osteoporosis in Type 2 Diabetic Postmenopausal Women: A Case-Control Study.

The study evaluates Asprosin's value in diabetic postmenopausal women, examining its reliability as a predictor for osteoporosis (OP) in the second ty...

Predicting Anti-inflammatory Peptides by Ensemble Machine Learning and Deep Learning.

Inflammation is a biological response to harmful stimuli, aiding in the maintenance of tissue homeostasis. However, excessive or persistent inflammati...

Shedding Light on Colorectal Cancer: An In Vivo Raman Spectroscopy Approach Combined with Deep Learning Analysis.

Raman spectroscopy has emerged as a powerful tool in medical, biochemical, and biological research with high specificity, sensitivity, and spatial and...

Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells.

OBJECTIVES: We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated im...

Vitamin D Deficiency in Patients Hospitalized for Heart Failure Living in the Tropics.

BACKGROUND AND OBJECTIVES: Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increase...

Fusion of electronic health records and radiographic images for a multimodal deep learning prediction model of atypical femur fractures.

Atypical femur fractures (AFF) represent a very rare type of fracture that can be difficult to discriminate radiologically from normal femur fractures...

Immune monitoring of allograft status in kidney transplant recipients.

Kidney transplant patients require careful management of immunosuppression to avoid rejection while minimizing the risk of infection and malignancy fo...

Unveiling Osteoporosis Through Radiomics Analysis of Hip CT Imaging.

RATIONALE AND OBJECTIVES: This study aims to investigate the use of radiomics analysis of hip CT imaging to unveil osteoporosis.

Automated vertebral bone mineral density measurement with phantomless internal calibration in chest LDCT scans using deep learning.

OBJECTIVE: To develop and evaluate a fully automated method based on deep learning and phantomless internal calibration for bone mineral density (BMD)...

A Concentric Tube Steerable Drilling Robot for Minimally Invasive Spinal Fixation of Osteoporotic Vertebrae.

Spinal fixation with rigid pedicle screws have shown to be an effective treatment for many patients. However, this surgical option has been proved to ...

A 48-Year-Old Man With a Hip Fracture and Skin Rash: A Case Report.

BACKGROUND/OBJECTIVE: Patients with systemic mastocytosis are at high risk of developing osteoporosis and fractures. Herein, we report a case of hip f...