Steroids

Beyond the guidelines: Vascular function as the central determinant and therapeutic target in hypertension.

Hypertension has traditionally been defined and managed according to brachial blood pressure levels. Although this pressure-centric strategy has significantly reduced cardiovascular morbidity and mortality, substantial residual risk persists even among patients who achieve recommended blood pressure targets. Emerging evidence indicates that hypertension is fundamentally a systemic disorder of the ...

Hair neuroendocrine signatures of acute stress reaction symptoms: Cross-national validation and latent profile heterogeneity.

The Acute Stress Reaction (ASR) involves transient emotional, somatic, cognitive, and behavioral symptoms after stressful exposure. Acute stress engages neuroendocrine responses and endocannabinoid systems (ECS), yet their joint links to multidimensional ASR symptoms remain unclear. This study characterizes coupling between hair-based neuroendocrine and ECS markers and ASR symptom dimensions, and ...

Systems biology integration of miR-mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis.

Approximately 60% of patients with ulcerative colitis (UC) show steroid resistance or dependence, underscoring the need for biomarkers predicting ther...

CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.

AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, extensive perineural invasion (PNI), ...

A machine learning-based framework for individualized physical activity and strength targets related to women's bone health.

While substantial evidence supports the associations between physical activity and bone health, the present study aims to advance the field by applyin...

Identification of TNFRSF12A as a key regulator of stemness and immunosuppression in a novel glioma subtype via multi-omics analysis and experimental validation.

Glioma stem cells (GSCs) drive tumor heterogeneity, therapy resistance, and immunosuppression. This study identified molecular subtypes of glioma base...

A Pharmaco-Epidemiological Research Program Leveraging a Nationwide Database of Kidney Transplantation.

OBJECTIVES: The pharmaco-epidemiological research program in kidney transplantation (PERP-KT) aims to evaluate, for the principal maintenance immunosu...

Baseline biochemical evaluation for etiologic differentiation in ACTH-dependent Cushing's syndrome: machine learning and composite score analysis in a multicenter cohort of 566 patients.

BACKGROUND: Limited availability of corticotropin-releasing hormone (CRH) currently complicates the differentiation of adrenocorticotropin (ACTH)-depe...

Automated readings of imaging reports by natural language processing (NLP) supplemented by clinical data predict disease course in children and adults with Crohn's disease: report from the epi-IIRN.

INTRODUCTION: The implementation of imaging features in administrative databases and electronic health records is limited by non-standardized free-tex...

Stress Reactions in Bone and Stress Fractures.

The term "stress fracture" encompasses a spectrum of bone injuries resulting from repetitive submaximal loading that exceeds the bone's capacity for r...

Clinical justification for osteoporosis investigation: transitioning from opportunistic to diagnostic referrals from alternative forms of imaging.

Clinical justification remains fundamental to the safe use of imaging involving ionising radiation, requiring a favourable balance between diagnostic ...

Identification and importance analysis of osteoporosis risk factors in perimenopausal women based on the Transformer-LSTM hybrid model and SMOTE.

OBJECTIVE: This study aimed to identify the core risk factors for osteoporosis in perimenopausal women and propose an analytical framework based on th...

The Metabolite indole-3-acetic acid of Bacteroides ovatus ameliorates ovariectomy-induced bone loss by activating AhR and inhibiting oxidative stress.

Postmenopausal osteoporosis represents a systemic skeletal condition distinguished by diminished bone mass and heightened skeletal fragility. Emerging...

Rewiring immunometabolism in hepato-biliary-pancreatic cancers: Unraveling TME-mediated metabolic suppression and advancing next-generation immunotherapeutic approaches.

Hepato-biliary-pancreatic cancers, notorious for their pronounced heterogeneity and poor prognosis, continue to be a dominant factor in cancer-related...

Perceptions of simulated artificial intelligence in medical consultations: associations with stress, memory, and perceived credibility.

The growing integration of digital technologies into healthcare requires understanding the impact of different consultation modalities on patient stre...

A machine learning-derived and functionally validated circadian rhythm signature predicts clinical outcomes and in silico drug sensitivity in colorectal cancer.

BACKGROUND: Colorectal cancer (CRC) displays considerable heterogeneity in clinical outcomes, highlighting the need for reliable prognostic biomarkers...

Identification of Methionine Metabolism-Driven Heterogeneous Subtypes in Colorectal Cancer and Their Associated Immune Microenvironment.

AIM: Tumor heterogeneity, driven by metabolic reprogramming, challenges colorectal cancer (CRC) treatment. Methionine metabolism is crucial for tumor ...

Single-cell and spatial transcriptomic landscapes reveal PIGT as a pivotal regulator of immunometabolic remodeling in colorectal cancer liver metastasis.

Colorectal cancer liver metastasis (CRLM) represents the leading cause of mortality in colorectal cancer (CRC). However, the molecular mechanisms enab...

Artificial intelligence predicts recurrent autoimmune hepatitis after liver transplantation in a multicenter cohort study.

BACKGROUND: Autoimmune hepatitis (AIH) is an important indication for liver transplantation (LT), but recurrence affects over 30% of recipients, threa...

MULTIPREVENT: Integrated screening for smoking-related multimorbidity using low-dose chest computed tomography.

OBJECTIVES: Tobacco consumption, combined with individual genetic predispositions, contributes to an age-dependent risk not only for lung cancer but a...