Steroids

Genomic scale analysis of assembly-line polyketide synthase diversity and evolution.

Covering: up to 2026Assembly-line polyketide synthases (PKSs) are among the most sophisticated catalysts in nature, responsible for the biosynthesis of many medicinally important natural products including antibiotics, anticancer agents, immunosuppressants and veterinary agents. While conventional methods for polyketide natural product discovery have fallen out of favor, the rapid expansion of mic...

Multidrug resistance in cancer: current understandings and future perspective.

Multidrug resistance (MDR) remains the core clinical barrier limiting the achievement of durable and effective treatment for various tumors. With the deepening of understanding, MDR has been redefined from the traditional, static "drug efflux" model to a systemically adaptive survival strategy driven by highly heterogeneous tumor populations under therapeutic pressure, characterized by dynamic evo...

Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer.

BACKGROUND: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain lar...

Immunosuppressive regimens and long-term kidney transplant outcomes: A dual survival modeling framework.

Optimizing immunosuppressive therapy remains central to improving long-term outcomes after kidney transplantation. Both induction and maintenance ther...

Integrated single-cell RNA sequencing and Bulk-RNA technologies reveal the immunological characteristics of lactylation related-genes in glioblastoma.

OBJECTIVE: Glioblastoma (GBM) is the most aggressive type of intracranial malignant tumor, known for its extremely poor prognosis. Lactylation, a newl...

Structure-based virtual screening identifies potential endogenous ligands of the human bitter taste receptor TAS2R46.

The sensing of bitter taste mediated by TAS2Rs serves as a defense mechanism against potentially harmful substances. The expression of TAS2Rs in extra...

IL4Rα blockade inhibits proliferation of malignant lymphocytes and the immunosuppressive tumor microenvironment of mycosis fungoides.

BACKGROUND: Limited therapeutic options are available for patients with advanced-stage mycosis fungoides (MF), and the 5-year survival rate is 25%. Du...

Molecular characteristics and modifications of glioblastoma affecting the efficacy of immunotherapy.

Glioblastoma is a highly aggressive brain tumor characterized by complex genetic, molecular, and epigenetic features that present significant challeng...

Identification of key predictors of postmenopausal osteoporosis from routine clinical indicators using explainable machine learning.

BACKGROUND: Machine learning (ML) shows promise in using clinical data to predict chronic diseases. However, its application in PMOP risk assessment u...

Efficacy and Hepatotoxicity of Psoralea corylifolia L.: A Meta-Analysis and Machine Learning Assessment in Postmenopausal Osteoporosis.

ETHNOPHARMACOLOGICAL RELEVANCE: Psoralea corylifolia L. (P. corylifolia, also known as Cullen corylifolium (L.) Medik.) is a traditional medicinal her...

Integrative multi-omics analysis and machine learning identify M2 macrophage-induced ferroptosis resistance in glioblastoma.

Glioblastoma (GBM) is characterized by profound intratumoral heterogeneity and an immunosuppressive microenvironment that drive therapeutic resistance...

A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response.

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a dismal prognosis, characterized by an immunosuppressive tumor microenviro...

Development of an automated landmarking tool for the femur in dual-energy X-ray absorptiometry scans using contour-based image analysis.

Osteoporosis is a skeletal disease that significantly increases fracture risk and imposes a growing public health and economic burden. Notably, hip fr...

Dissecting T-cell exhaustion heterogeneity and immune ecosystem dynamics in colorectal cancer through multi-omics machine learning.

BACKGROUND: Immunotherapy has shown limited efficacy in a substantial subset of CRC patients, yet the mechanisms underlying therapeutic resistance rem...

Sweat-based electrochemical wearable biosensors for sports performance and fatigue monitoring: from laboratory prototypes to field deployment.

Wearable biosensing technologies are advancing sports performance monitoring by enabling the continuous and real-time measurement of physiological and...

AI-derived bone mineral density from standard radiographs compared with DXA for fracture prediction in a 10-year real-world cohort study.

UNLABELLED: AI-derived bone mineral density from routine radiographs showed strong agreement with DXA and comparable ability to predict incident fract...

Multi-Omics Analysis Identifies Paxillin as a Biomarker of Doxorubicin Resistance via Cytoskeletal Remodeling and Immune Exhaustion.

Chemotherapy resistance remains a primary cause of treatment failure in breast cancer, yet the global proteomic landscape driving this phenotype has n...

Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients.

BACKGROUND: Donor-specific antibodies (DSA) against human leukocyte antigens (HLA) are associated with increased immunologic risk in kidney transplant...

Mechanism-Based Multitarget Modeling for Pathway-Level Prediction of PI3K/Akt Signaling Perturbation Induced by Liquid Crystal Monomers.

Liquid crystal monomers (LCMs) are emerging contaminants whose system-level toxicity mechanisms remain poorly understood. Here, we developed a pathway...

Clinical Implementation of Opportunistic Screening for Osteoporosis.

Opportunistic screening leverages existing imaging examinations performed for unrelated routine clinical indications to systematically extract quantit...