Cardiovascular

Strokes

Latest AI and machine learning research in strokes for healthcare professionals.

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Evidential Perfusion Physics-Informed Neural Networks with Residual Uncertainty Quantification

Physics-informed neural networks (PINNs) have shown promise in addressing the ill-posed deconvolution problem in computed tomography perfusion (CTP) imaging for acute ischemic stroke assessment. However, existing PINN-based approaches remain deterministic and do not quantify uncertainty associated with violations of physics constraints, limiting reliability assessment. We propose Evidential Perfus...

Mar 10 2026 2603.09359v1

Automated high-throughput fabrication of patient-specific vessel-on-chips enables a generative AI digital twin--Cascade Learner of Thrombosis (CLoT) for personalized thrombosis prediction

We developed an integrated platform combining high-throughput automated biofabrication, systematic patient-derived tissue experiments, and specialized artificial intelligence to enable patient-specific computational "digital twins" for thrombosis prediction. Our automated manufacturing platform fabricates 80 fully assembled, patient-specific vessel-on-chips within 10 hours from clinical imaging--a...

CRESTomics: Analyzing Carotid Plaques in the CREST-2 Trial with a New Additive Classification Model

Accurate characterization of carotid plaques is critical for stroke prevention in patients with carotid stenosis. We analyze 500 plaques from CREST-2,...

Mar 4 2026 2603.04309v1
Conversational artificial intelligence HeAlth supporT in Atrial Fibrillation Self-Management (CHAT-AF-S): rationale and randomised controlled trial design

Introduction: Atrial fibrillation (AF), a common arrhythmia, is associated with impaired quality of life (QoL) and increased stroke risk and mortality...

Frequency-dependent diffusion tensor distribution imaging in the evaluation of ischemic stroke

Non-invasive MRI is widely used to assess and monitor ischemic stroke, yet conventional approaches often lack sensitivity to subtle microstructural ch...

Clinically-aligned ischemic stroke segmentation and ASPECTS scoring on NCCT imaging using a slice-gated loss on foundation representations

Rapid infarct assessment on non-contrast CT (NCCT) is essential for acute ischemic stroke management. Most deep learning methods perform pixel-wise se...

Feb 27 2026 2602.23961v1
Machine learning-based prediction of cardiovascular disease risk in Africa using WHO Stepwise Surveys: 2014-2019

Introduction: Cardiovascular diseases (CVDs) are the leading cause of death globally, with rising burdens in Africa due to ageing populations, lifesty...

From Blind Spots to Gains: Diagnostic-Driven Iterative Training for Large Multimodal Models

As Large Multimodal Models (LMMs) scale up and reinforcement learning (RL) methods mature, LMMs have made notable progress in complex reasoning and de...

Feb 26 2026 2602.22859v1
Breaking Semantic-Aware Watermarks via LLM-Guided Coherence-Preserving Semantic Injection

Generative images have proliferated on Web platforms in social media and online copyright distribution scenarios, and semantic watermarking has increa...

Feb 25 2026 2602.21593v1
AI-based Speech Error Detection to Differentiate Primary Progressive Aphasia Variants

Background: Artificial Intelligence (AI) based approaches to speech analysis have the potential to assist with objective speech error analysis in apha...

Restoring brain-to-text communication in a person with dysarthria from pontine stroke using an intracortical brain-computer interface

Restoring communication for people with dysarthria secondary to pontine stroke remains a critical challenge. Intracortical brain-computer interfaces (...

Prompting is All You Need: How to Make LLMs More Helpful for Clinical Decision Support

Importance: Large language models (LLMs) offer potential decision support, but their accuracy varies. Prompt engineering can generally enhance LLM beh...

AI-Detected Asymptomatic Atrial Fibrillation and Risk of Incident Ischemic Stroke and Cardiovascular Events: A UK Biobank Study

Background: Advances in wearable devices and machine-learning-based ECG analysis enable highly accurate detection of atrial fibrillation (AF) outside ...

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

Objective: Electronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet...

The Sound of Death: Deep Learning Reveals Vascular Damage from Carotid Ultrasound

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, yet early risk detection is often limited by available diagnostics. Ca...

Feb 19 2026 2602.17321v1
AI-DRIVEN DIAGNOSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ASSOCIATED COMORBIDITIES

Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent hepatic condition caused by the buildup of fat in the liver. It is frequently associ...

VideoSketcher: Video Models Prior Enable Versatile Sequential Sketch Generation

Sketching is inherently a sequential process, in which strokes are drawn in a meaningful order to explore and refine ideas. However, most generative m...

Feb 17 2026 2602.15819v1
StrokeNeXt: A Siamese-encoder Approach for Brain Stroke Classification in Computed Tomography Imagery

We present StrokeNeXt, a model for stroke classification in 2D Computed Tomography (CT) images. StrokeNeXt employs a dual-branch design with two ConvN...

Feb 16 2026 2602.15087v1
Formally Verifying and Explaining Sepsis Treatment Policies with COOL-MC

Safe and interpretable sequential decision-making is critical in healthcare, yet reinforcement learning (RL) policies for sepsis treatment optimizatio...

Feb 16 2026 2602.14505v1
Single-Cell and Spatial Transcriptomics Integration Identifies Mural Cell Oxidative Stress Genes Clu and Gria2 as Key Biomarkers in Ischemic Stroke

Oxidative stress (OS) is a key factor in ischemic stroke (IS), but the characterization of OS-related genes in IS remains largely unexplored. Identify...

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