Transplantation

Effects of Proud Large Osteochondral Plugs on Contact Forces and Knee Kinematics: A Robotic Study.

BACKGROUND: Osteochondral allograft (OCA) transplantation is used to treat large focal femoral condylar articular cartilage defects. A proud plug could affect graft survival by altering contact forces (CFs) and knee kinematics.

Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery.

The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. Here, a universal micromagnet junction for self-navigating gates of...

Linking of single-molecule experiments with molecular dynamics simulations by machine learning.

Single-molecule experiments and molecular dynamics (MD) simulations are indispensable tools for investigating protein conformational dynamics. The for...

Physical Properties of the Extracellular Matrix of Decellularized Porcine Liver.

The decellularization of organs has attracted attention as a new functional methodology for regenerative medicine based on tissue engineering. In prev...

Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence.

Human lungs are susceptible to the toxicity induced by soluble xenobiotics. However, the direct cellular effects of many pulmonotoxic chemicals are no...

Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia.

Hybridization and gene flow between species appears to be common. Even though it is clear that hybridization is widespread across all surveyed taxonom...

Human Splice-Site Prediction with Deep Neural Networks.

Accurate splice-site prediction is essential to delineate gene structures from sequence data. Several computational techniques have been applied to cr...

Creating Clinical Fuzzy Automata with Fuzzy Arden Syntax.

Formal constructs for fuzzy sets and fuzzy logic are incorporated into Arden Syntax version 2.9 (Fuzzy Arden Syntax). With fuzzy sets, the relationshi...

Efficient organ localization using multi-label convolutional neural networks in thorax-abdomen CT scans.

Automatic localization of organs and other structures in medical images is an important preprocessing step that can improve and speed up other algorit...

Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation.

The objective of the current study was to explore the role of ABCB1 and CYP3A5 genetic polymorphisms in predicting the bioavailability of tacrolimus a...

Physical Compatibility and Chemical Stability of Injectable and Oral Ranitidine Solutions.

The physical compatibility and chemical stability of ranitidine hydrochloride injectable solutions and oral syrup were studied to define beyond-use d...

Machine Learning of Partial Charges Derived from High-Quality Quantum-Mechanical Calculations.

Parametrization of small organic molecules for classical molecular dynamics simulations is not trivial. The vastness of the chemical space makes appro...

Improving prediction of heart transplantation outcome using deep learning techniques.

The primary objective of this study is to compare the accuracy of two risk models, International Heart Transplantation Survival Algorithm (IHTSA), dev...

Machine Learning Algorithms Utilizing Quantitative CT Features May Predict Eventual Onset of Bronchiolitis Obliterans Syndrome After Lung Transplantation.

RATIONALE AND OBJECTIVES: Long-term survival after lung transplantation (LTx) is limited by bronchiolitis obliterans syndrome (BOS), defined as a sust...

Re: Robot-Assisted Kidney Transplantation: The European Experience.

Clinical success of IUI cycles with donor sperm is not affected by total inseminated volume: a RCT.

STUDY QUESTION: What is the impact on live birth rates (LBR) when a donor IUI (dIUI) cycle is performed with an insemination volume of 0.5 mL versus t...

Female Choice Leads to a Switch in Oval Squid Male Mating Tactics.

Oval squids are polyandrous, with one female mating with multiple males during the spawning season. There are two alternative male mating tactics used...

Evaluation of a Machine Learning-Based Prognostic Model for Unrelated Hematopoietic Cell Transplantation Donor Selection.

The survival of patients undergoing hematopoietic cell transplantation (HCT) from unrelated donors for acute leukemia exhibits considerable variation,...

Spatial aggregation of holistically-nested convolutional neural networks for automated pancreas localization and segmentation.

Accurate and automatic organ segmentation from 3D radiological scans is an important yet challenging problem for medical image analysis. Specifically,...

Analysis of Spatio-Temporal Representations for Robust Footstep Recognition with Deep Residual Neural Networks.

Human footsteps can provide a unique behavioural pattern for robust biometric systems. We propose spatio-temporal footstep representations from floor-...