Latest AI and machine learning research in transplantation for healthcare professionals.
BACKGROUND: The low positive predictive value of HLA-B∗15:02 and HLA-B∗58:01 for risk stratification of carbamazepine (CBZ) and allopurinol (ALLO) induced severe cutaneous adverse reactions (SCARs) suggests that we need a better model to prevent cases. OBJECTIVE: This study aims to comprehensively investigate the role of genomic factors in CBZ- and ALLO-induced SCARs using machine-learning. METHOD...
BACKGROUND: End-stage renal disease (ESRD) is a severe chronic renal disorder with high mortality, requiring dialysis treatment or kidney transplantation. The endothelial activation and stress index (EASIX), reflecting inflammatory status and endothelial dysfunction, has demonstrated predictive value for outcomes in multiple diseases. However, its association with in-hospital mortality (IHM) risk ...
This review explores the application and limitations of ultrasound elastography (USE) in the pediatric population, addressing its diagnostic value acr...
The heterogeneity and immunosuppressive characteristics of the tumor microenvironment present significant challenges to traditional treatment strategi...
INTRODUCTION: Adverse drug reactions remain a major barrier to drug development, with hepatotoxicity representing a persistent cause of clinical failu...
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with therapeutic efficacy often hindered by late-stage diagnosis, c...
Single-walled carbon nanotubes (SWCNTs) act as one-dimensional (1D) nanoreactors capable of stabilizing reactive species and unique low-dimensional ph...
Mechanistic studies of liquid-liquid phase separation (LLPS) have increasingly revealed that cells achieve multiscale and highly precise regulation of...
Physiologically relevant liver models are essential for advancing hepatic disorder research, especially for disease modeling and drug development, yet...
BACKGROUND: The rising co-occurrence of cardiometabolic diseases and musculoskeletal degeneration poses a critical challenge to healthy aging, yet the...
T-cell bispecific antibodies (TCBs), a specialized subclass of bispecific antibodies (BsAbs), are engineered to simultaneously engage T cells and tumo...
Tissue engineering, rooted in cell biology and materials science, focuses on repairing or replacing injured tissues and organs, offering groundbreakin...
Organ transplantation remains a gold-standard intervention for numerous end-stage organ failure diseases. However, allograft rejection is still a barr...
PURPOSE: To evaluate the accuracy of automatic surface tracking registration with a smartphone augmented reality (AR) guidance system for percutaneous...
Cancer-associated fibroblasts (CAFs) are major stromal components of the tumor microenvironment (TME) and play diverse roles in gastrointestinal (GI) ...
BACKGROUND: Ammonia, which was traditionally regarded as a metabolic by-product, has more recently emerged as a crucial regulator of tumor metabolism ...
PURPOSE OF REVIEW: Asthma continues to pose a serious global health issue affecting billions of people and causing significant morbidity. It is immuno...
Deep learning and prior-image-guided cross modality motion reconstruction methods have recently en abled faster acquisition time and lower artifacts i...
Across Africa, substantial investment has built national health information systems (HISs), including the surveillance platforms, reporting tools, and...
The superior image quality and excellent contrast offered by Magnetic Resonance Imaging (MRI) make it an ideal tool for guiding interventional procedu...