Transplantation

Latest AI and machine learning research in transplantation for healthcare professionals.

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Designing proteins with reduced T-cell epitopes through policy optimization

Deep generative models for protein structure and sequence are increasingly used to design proteins w...

Protein Dimension DB: A Unified Protein Repository for Representation Learning and Functional Analysis

Inspired by the success of large language models in areas like natural language processing, research...

Normalized Raman Imaging for Studies of Tissue Physiology of the Kidney

Histology is the cornerstone of clinical pathology and an essential tool for many areas of medicine....

IMMUNIA: A Multi-LLM Reasoning Agent for Immunoregulatory Surfaceome Discovery

Biomarker discovery for immunotherapy often requires reasoning across complex immune contexts. We pr...

Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics

CRISPR-associated transposons (CAST) use guide RNAs to direct their transposition and are being harn...

PULSAR: a Foundation Model for Multi-scale and Multicellular Biology

Biology emerges from interactions across physical scales, where molecular interactions drive cellula...

Learning the Unseen: Data-Augmented Deep Learning for PTM Discovery with Prosit-PTM

Post-translational modifications (PTMs) are critical regulators of protein function, yet confidently...

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

Circulating non-cellular factors, such as plasma proteins, contribute to various features of aging. ...

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

The Spatial Atlas of Human Anatomy (SAHA) represents the first multimodal, subcellular- resolution r...

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson’s disease

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Pa...

Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection

Long-term transplant success is limited by allograft rejection, a complex process traditionally stud...

Single recipient cell tracking of tellurium-labeled extracellular vesicle proteomes (TeLEV) identifies EV-driven immunomodulation

Extracellular vesicles (EVs) mediate tumor-immune cell communication by carrying protein cargo that ...

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation

Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagat...

GPTAnno: Ontology-tree-guided hierarchical cell type annotation based on GPT models for single-cell data

Cell type annotation is critical for interpreting single-cell transcriptomic data but remains challe...

ROSIE-Enabled Spatial Mapping Reveals Architectural Fragmentation and Immune Reprogramming in Lung Adenocarcinoma Evolution

The progression of lung adenocarcinoma (LUAD) from precancerous lesions to invasive carcinoma entail...

Biologically Inspired Digital Histology for Deep Phenotyping of Placental Composition Changes Across Major Lesion Types

Placenta pathology provides diagnostic insights for understanding pregnancy complications and guides...

Asymmetric Cross-Reactivity of Nuclear Receptors Reveals an Evolutionary Buffer Between Estrogen and Androgen Signaling

A comprehensive all-by-all receptor ligand affinity screen using Boltz-2, a deep learning framework ...

Ensemble-DeepSets: an interpretable deep learning framework for single-cell resolution profiling of immunological aging

Immunological aging (immunosenescence) drives increased susceptibility to infections and reduced vac...

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