Latest AI and machine learning research in transplantation for healthcare professionals.
Understanding the behavioral and morphological dynamics of moving model organisms like the zebrafish larvae requires accurate, high-throughput 3D analysis. However, traditional single-view 2D video tracking fails to capture the full scope of natural 3D movements and postural dynamics. Here, we present a novel high-throughput 24-camera array microscope with a co-designed “mirrored well plate” that ...
Glioblastoma (GBM), the most aggressive primary brain tumor in adults, exhibits profound treatment resistance and poor prognosis. Despite advances in immunotherapy for other cancers, GBM remains refractory, potentially due to its lactate-rich, immunosuppressive tumor microenvironment (TME). While aerobic glycolysis-driven lactate accumulation is known to acidify the TME and impair immune function,...
Large foundation models have revolutionized single-cell analysis, yet no kidney-specific model currently exists, and it remains unclear whether organ-...
The rational design of high-specificity binders to peptide–HLA (pHLA) complexes remains a major challenge in personalized immunotherapy, particularly ...
Neural transplantation holds the potential to repair damaged neural circuits in neurological diseases. However, it remains unknown how the grafted neu...
Hydrogen-deuterium exchange/mass spectrometry (HX/MS) is a rapidly expanding technique used to investigate protein conformational ensembles. The growi...
Glioblastoma (GBM), the most aggressive primary brain tumor, has a median survival of approximately 15 months. Twenty percent of patients survive beyo...
Deep generative models for protein structure and sequence are increasingly used to design proteins with therapeutic and industrial applications, but t...
Inspired by the success of large language models in areas like natural language processing, researchers have applied similar architectures, notably th...
Histology is the cornerstone of clinical pathology and an essential tool for many areas of medicine. Nevertheless, conventional histological methods, ...
High-throughput RNA-sequencing has significantly advanced transcriptomic profiling in on-cology. Millions of RNA-seq datasets have accumulated in publ...
Biomarker discovery for immunotherapy often requires reasoning across complex immune contexts. We present IMMUNIA, a multi-large-language-model (multi...
CRISPR-associated transposons (CAST) use guide RNAs to direct their transposition and are being harnessed as tools for programmable genome engineering...
Biology emerges from interactions across physical scales, where molecular interactions drive cellular states, which in turn orchestrate multicellular ...
Post-translational modifications (PTMs) are critical regulators of protein function, yet confidently identifying and localizing PTM sites across prote...
Circulating non-cellular factors, such as plasma proteins, contribute to various features of aging. To determine the impacts of endogenous circulating...
The Spatial Atlas of Human Anatomy (SAHA) represents the first multimodal, subcellular- resolution reference of healthy adult human tissues across mul...
Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD) and often increase kinase a...
Long-term transplant success is limited by allograft rejection, a complex process traditionally studied on an organ-specific basis. To establish a uni...
This work introduces a modular, open-source computational pipeline for glioblastoma (GBM) vaccine design that integrates omics-based OIP5 target disco...