Transplantation

Latest AI and machine learning research in transplantation for healthcare professionals.

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Advances in Cell Therapy for Neural Repair.

Neural repair remains one of the foremost challenges in modern neuroscience, as damage to the central nervous system caused by injury or neurodegenerative disease often leads to irreversible loss of function. The advent and rapid evolution of utilizing stem cell biology have provided unprecedented opportunities to advance regenerative strategies aimed at restoring brain and spinal cord integrity, ...

Apr 29 2026 42055920

Development and Application of Organoids for Toxicology Studies.

Organoids are 3D in vitro models derived from human stem cells, capable of simulating the structure, function, and intercellular interactions of human organs to a high degree. In recent years, organoid research in toxicology has deepened, with applications spanning drug toxicity, environmental toxicity, and food toxicity. Current research focuses on elucidating molecular pathways of toxin action, ...

Apr 29 2026 42056005
Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs.

Female reproductive aging has systemic health implications, yet tissue-level dynamics remain poorly understood. Here we integrate deep learning analys...

Apr 29 2026 42056282
A pilot study on the impact of large language model assistance on the evaluation of complex medical living kidney donor candidates.

BACKGROUND: Large language models (LLMs) are undergoing exploration as clinical decision support tools. However, their role in complex, high-stakes tr...

Apr 29 2026 42049664
Precision Medicine in Autoimmune Thyroid Diseases: Decoding Biomarkers, Targeted Therapies and Digital Innovation.

INTRODUCTION: Autoimmune thyroid diseases (AITDs), including Graves' disease and Hashimoto's thyroiditis, arise from genetic, epigenetic, and environm...

Apr 28 2026 42047347
Evaluation of AI-Driven Automatic Segmentation Algorithms for Lung Shunt Fraction Estimation in 90Y-Labeled Microsphere Therapy.

90Y-labeled microsphere (90Y-microsphere) hepatic arterial radioembolization is a direct treatment for hepatic neoplasms. Before therapy, the fraction...

Apr 28 2026 42049455
Cigarette smoking and long-term incidence of colorectal cancer subclassified by tumor-infiltrating myeloid cells: A prospective cohort study.

Evidence indicates that cigarette smoking affects anti-tumor immunity. We tested a hypothesis that the association of smoking with long-term colorecta...

Apr 27 2026 42055208
Beyond HLA-Ia: A multidimensional framework for Neoantigen immunotherapy.

Glioblastoma (GBM) and other malignant gliomas are associated with aggressive progression, high recurrence rates, and poor long-term outcomes, while c...

Apr 27 2026 42061113
Machine Learning Models Using Hospital Admission Characteristics Do Not Optimally Predict Nosocomial Infection Development in a Global Cirrhosis Cohort.

BACKGROUND: Nosocomial infections (NI) in cirrhosis are associated with high mortality but could be preventable. Logistic regression (LR) models have ...

Apr 27 2026 42043180
DDA-BERT: end-to-end training for data-dependent acquisition mass spectrometry-based proteomics.

Peptide-spectrum match (PSM) rescoring is critical for accurate peptide identification in data-dependent acquisition (DDA)-based proteomics. Existing ...

Apr 27 2026 42045233
Emerging multidimensional biomarker system for cardiovascular-kidney-metabolic syndrome: from multi-omics integration to clinical artificial intelligence.

Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging clinical entity that highlights the complex, bidirectional interplay among cardiovascula...

Apr 26 2026 42036643
A machine learning-driven framework integrating cell death and senescence signatures for multi-target drug design and immunotherapy optimization in ovarian cancer.

Ovarian cancer (OC) remains therapeutic challenge due to its complex molecular heterogeneity and therapy-induced adaptive resistance. While non-apopto...

Apr 26 2026 42034671
A macrophage co-expression signature enables robust prognostic prediction in glioblastoma.

BACKGROUND: Glioblastoma (GBM) exhibits profound cellular heterogeneity and a highly immunosuppressive microenvironment in which tumor-associated macr...

Apr 25 2026 42035563
Multi-stimuli and AI-guided electrically-responsive self-healing nanocomposites for low-temperature structural applications.

Self‑healing nanocomposites capable of operating under sub‑ambient aerospace conditions remain limited by slow reaction kinetics, single‑stimulus acti...

Apr 25 2026 42034711
Delisting From Clinical Improvement in Liver Cirrhosis: A Machine Learning Decision Tree Analysis.

BACKGROUND: Following therapeutic advancements, recompensation has gained increasing recognition in patients on waitlist for liver transplantation (LT...

Apr 24 2026 42302272
Applying microbial ecology frameworks to microbial therapies for wildlife.

Microbial ecology is increasingly incorporated into human and animal medicine via the study and purposeful manipulation of host-associated microbiomes...

Apr 24 2026 42029022
Optimizing Ternary Preparation Parameters of Thin-Film Nanocomposite Membranes for Tailored Selectivity via Interpretable Machine Learning.

Novel thin-film nanocomposite (TFN) nanofiltration membranes have attracted wide attention for their generally boosted water permeability. However, th...

Apr 24 2026 42029929
Time for a new category: "acute-on-chronic" hypertensive target organ damage.

INTRODUCTION: The aims of the paper are: 1) To analyze the evolution of understanding of hypertensive target organ damages (TODs)); 2) To see if the c...

Apr 24 2026 42030043
Heterogeneity of depression and suicidal ideation among college students in Eastern China: a latent profile analysis and machine learning approach.

To investigate the heterogeneity of depression and suicidal ideation among Chinese college students and to examine the roles of family and individual ...

Apr 24 2026 42032089
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