Transplantation

Prediction of delayed graft function after deceased donor kidney transplantation: development and temporal validation in a single-center cohort.

[Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].

Cranio-maxillofacial bone defects resulting from trauma, tumors, infection, or congenital malformations not only severely impair patients' physiological functions, but also impose a profound psychological burden, constituting a major public health issue that affects overall health and quality of life. Conventional reconstructive approaches, including autologous grafting and allogeneic implantation...

[Research progress in clinical pathology and molecular mechanisms of pancreatic adenosquamous carcinoma].

Pancreatic adenosquamous carcinoma (PASC) is a rare exocrine malignancy of the pancreas with an increasing incidence, histologically defined by the co...

Development and validation of a fully automated transformer-based 3D framework for pancreatic fat quantification in pancreatic steatosis.

PURPOSE: To develop and validate a fully automated TransUNet-based framework for 3D pancreatic segmentation and volumetric fat quantification on PDFF ...

Novel therapeutic strategies for metastatic castration‑resistant prostate cancer: Beyond androgen receptor pathway inhibition (Review).

Metastatic castration‑resistant prostate cancer (mCRPC) remains a lethal disease due to universal resistance to androgen‑receptor pathway inhibitors (...

HySimODE: A hybrid stochastic-deterministic simulation framework for multiscale models of biological systems.

Hybrid simulation is essential for modeling biochemical systems that mix low-copy stochastic dynamics with high-abundance deterministic processes. We ...

Advances in HLA and Non-HLA Immune Profiling: Integrating Next-Generation Sequencing and Artificial Intelligence in Transplantation.

Understanding transplantation outcomes requires an integrated view of immunological, genetic, and clinical determinants that collectively shape graft ...

NetMHCIIphosPan: A Machine Learning Tool for Predicting HLA Class II Antigen Presentation of Phosphorylated Peptides.

Phosphorylated peptides presented by human leukocyte antigen (HLA) class II molecules play pivotal roles in immune regulation, yet their characterizat...

Exploring the potential targets and mechanisms of malachite green induced lung adenocarcinoma through network toxicology and molecular docking.

Malachite green (MG), a synthetic dye, has turned into a major risk to human health, because of its toxicity of teratogenic, genotoxic, carcinogenic, ...

Industry-Sponsored Research Payments in Radiology: A National Open Payments Analysis.

INTRODUCTION: Industry funding for research is important in the era of decreasing federal research support. The goal of this study was to assess the t...

Reduction of Acquisition Time in FTIR Spectroscopy via Spectral Super-Resolution by Deep Learning.

This study aims to enhance spectral resolution in Fourier transform infrared spectroscopy (FTIR), a crucial element for in-depth molecular analysis in...

Unraveling defect-mediated ion transport behavior in anti-perovskite solid-state electrolytes via machine learning molecular dynamics simulations.

Anti-perovskite (AP) solid-state electrolytes (SSEs) have emerged as promising candidates for high-safety solid-state batteries due to their wide elec...

AI-guided discovery of the IRF4-PAICS-LDHA axis as a multitarget hub linking tumor metabolism to CD8+ T cell exhaustion in DLBCL.

Diffuse large B-cell lymphoma (DLBCL) features an immunosuppressive tumor microenvironment (TME), yet the molecular drivers connecting metabolic repro...

Divergent synthesis of γ-lactones and cyclopropanes via efficient [1 + 4] and [1 + 2] annulations of amide-sulfoxonium ylides.

Functionalized γ-lactones and cyclopropanes, especially those bearing amide substituents, play important roles in diverse chemical and pharmacological...

Molecular Biomarkers and Risk Prediction Models for Acute Kidney Injury Following Liver Transplantation: A Review.

Liver transplantation is the definitive treatment for end-stage liver disease; however, postoperative acute kidney injury (AKI) affects 30%-70% of rec...

X2Shape: CT-free 3D multi-organ reconstruction with biplanar X-rays.

Reconstructing three-dimensional (3D) anatomy from routine X-ray imaging remains a long-standing challenge, promising high accessibility and minimal r...

From pathogenesis to precision medicine in systemic lupus erythematosus: Emerging biomarkers and targeted interventions.

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by immune dysregulation, autoantibody production, and chron...

Machine learning-based multi-omic analysis identifies CEP55, DLGAP5, and EZH2 as regulated cell death biomarkers linked to immunotherapy resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) often exhibits limited responsiveness to immune checkpoint inhibitors (ICIs), largely due to an immunosuppressive tumor...

Haploidentical versus matched unrelated donor transplantation with post-transplant cyclophosphamide: a platform-dependent machine learning analysis of donor age.

In allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide (PTCy), clinicians frequently face a critical choice between a ...

Cross-task interpretability through unified modeling reveals a universal shortcut bias in neoantigen prediction.

Accurate neoantigen prediction is central to the design of personalized cancer immunotherapy. The immune recognition of neoantigens is a multi-step pr...