Transplantation

Bridging machine learning and clinical practice: a multicentre nomogram for 90-day graft failure risk stratification in heart transplantation.

BACKGROUND: Early graft failure within 90 postoperative days is the leading cause of mortality after...

Integrating network toxicology, machine learning, and molecular dynamics simulations to reveal tanshinone iia's dual mechanisms in TNBC and doxorubicin-induced cardiotoxicity.

Doxorubicin (Dox)-induced cardiotoxicity remains a critical barrier to optimizing breast cancer (BC)...

Comprehensive tumour-immune profiling reveals TREM2+ tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma.

BACKGROUND: Lymph node (LN) metastasis is a well-established independent prognostic factor in head a...

Effects of ABO-Incompatible Blood Transfusion on Immune Response and Rejection After Organ Transplantation.

BACKGROUND: Peri-operative blood transfusion is common during solid-organ transplantation, yet the i...

A Scoping Review of the Photographic Assessment of Donor Liver Steatosis in Transplantation Using Artificial Intelligence.

INTRODUCTION: Accurate evaluation of liver steatosis and overall organ quality is critical for optim...

Machine learning mortality prediction model for cyclosporine therapy in pediatric aplastic anemia.

The outcomes of children with aplastic anemia receiving cyclosporine monotherapy vary significantly ...

Early Implications for Solid Organ Transplantation With the Use of Artificial Intelligence From a Bibliometric Perspective.

Artificial intelligence (AI) is increasingly transforming health care, particularly in solid organ t...

You Didn't Think It Would Be That Easy, Did You? Commentary on "Machine Learning Predictions for Assessing Hard-to-Place Deceased Donor Kidneys".

Machine Learning Predictions for Assessing Hard-to-Place Deceased Donor Kidneys.

RATIONALE & OBJECTIVE: Nearly 20% of deceased donor kidneys in the United States are placed "out-of-...

Machine Learning Algorithms to Predict Venous Thromboembolism in Patients With Sepsis in the Intensive Care Unit: Multicenter Retrospective Study.

BACKGROUND: Venous thromboembolism (VTE) is a common and severe complication in intensive care unit ...

Group equivariant pyramid network for respiratory motion correction on PET image.

INTRODUCTION: Respiratory-induced artefacts cause blurring in PET images, impairing lesion identific...

The autonomy paradox in AI-generated content adoption: Creative-specific alternative to TAM model in China's micro-short drama industry.

In China's booming micro-short drama industry, Artificial Intelligence Generated Content (AIGC) pres...

Guided electron flow in anthraquinone-methoxy donor-acceptor1-acceptor2 covalent triazine frameworks enabling superior selective uranium capture.

Rational design and synthesis of stable and efficient photocatalysts for selective U(VI) capture in ...

Microvascular inflammation in the kidney transplant, beyond acute antibody-mediated rejection.

PURPOSE OF REVIEW: Microvascular inflammation (MVI) is a central feature of allograft rejection, tra...

Hemoglobin as a Molecular Glue: Toward Potent Inhibition of HbS Polymerization in Sickle Cell Disease.

Sickle cell disease (SCD), a monogenic disorder arising from a single point mutation in the β-globin...

"Comprehensive multi-omics of age-respective plasma and matrix-bound extracellular vesicles identifies anti-fibrotic miRNAs validated on a heart-on-a-chip".

Aging is a major risk factor for cardiovascular disease, the leading cause of death worldwide, and n...

Organ preservation in rectal cancer: an endoscopist's perspective on current evidence and future directions.

Rectal cancer management has increasingly shifted toward organ-preserving strategies that aim to mai...

Forecasting Waitlist Trajectories for Patients With Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis: A Neural Network Competing Risk Analysis.

BACKGROUND: Metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis is a leading indicatio...

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson's disease.

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Pa...

Radiomics-based gradient boosting model on contrast-enhanced MRI for non-invasive prediction of epidermal growth factor receptor expression and therapeutic response to EGFR-targeted antibody-drug conjugates in high-grade glioma organoid models.

BACKGROUND: Epidermal growth factor (EGF) and its receptor EGF(EGFR) play crucial roles in glioblast...

Data-Integrated Elucidation of Structure-Activity Relationships toward the Rational Design of Perfluoroiodoarene-Based Halogen-Bond Donor Catalysts.

Understanding and predicting catalyst performance from structural and electronic information remains...