Transplantation

Effects of ABO-Incompatible Blood Transfusion on Immune Response and Rejection After Organ Transplantation.

BACKGROUND: Peri-operative blood transfusion is common during solid-organ transplantation, yet the impact of ABO-incompatible (ABOi) blood exposure on post-transplant immunity and acute rejection (AR) remains uncertain. METHODS: We assembled a multicenter cohort of 468 adult kidney, liver and heart recipients (2018-2024). Detailed, time-stamped transfusion records were linked to serial immune-phen...

A Scoping Review of the Photographic Assessment of Donor Liver Steatosis in Transplantation Using Artificial Intelligence.

INTRODUCTION: Accurate evaluation of liver steatosis and overall organ quality is critical for optimizing safe organ utilization in liver transplantation. Recent advances in computer vision offer promising tools to standardize and enhance this process. This review maps the current evidence on AI-enabled photographic evaluation of liver steatosis and identifies areas for future development. METHODS...

Machine learning mortality prediction model for cyclosporine therapy in pediatric aplastic anemia.

The outcomes of children with aplastic anemia receiving cyclosporine monotherapy vary significantly in terms of mortality risk; therefore, a prognosti...

Early Implications for Solid Organ Transplantation With the Use of Artificial Intelligence From a Bibliometric Perspective.

Artificial intelligence (AI) is increasingly transforming health care, particularly in solid organ transplantation, where it addresses complex challen...

You Didn't Think It Would Be That Easy, Did You? Commentary on "Machine Learning Predictions for Assessing Hard-to-Place Deceased Donor Kidneys".

Machine Learning Predictions for Assessing Hard-to-Place Deceased Donor Kidneys.

RATIONALE & OBJECTIVE: Nearly 20% of deceased donor kidneys in the United States are placed "out-of-sequence" (ie, outside of standard allocation rule...

Machine Learning Algorithms to Predict Venous Thromboembolism in Patients With Sepsis in the Intensive Care Unit: Multicenter Retrospective Study.

BACKGROUND: Venous thromboembolism (VTE) is a common and severe complication in intensive care unit (ICU) patients with sepsis. Conventional risk stra...

Group equivariant pyramid network for respiratory motion correction on PET image.

INTRODUCTION: Respiratory-induced artefacts cause blurring in PET images, impairing lesion identification and diagnosis. Existing correction methods e...

The autonomy paradox in AI-generated content adoption: Creative-specific alternative to TAM model in China's micro-short drama industry.

In China's booming micro-short drama industry, Artificial Intelligence Generated Content (AIGC) presents creators with an 'autonomy paradox': improvin...

Guided electron flow in anthraquinone-methoxy donor-acceptor1-acceptor2 covalent triazine frameworks enabling superior selective uranium capture.

Rational design and synthesis of stable and efficient photocatalysts for selective U(VI) capture in water remains a great challenge due to the complic...

Microvascular inflammation in the kidney transplant, beyond acute antibody-mediated rejection.

PURPOSE OF REVIEW: Microvascular inflammation (MVI) is a central feature of allograft rejection, traditionally associated with antibody-mediated rejec...

Water parks, vaping, COPD topics on team management, exacerbations, bronchoscopic therapies, lung transplantation, and artificial intelligence.

Hemoglobin as a Molecular Glue: Toward Potent Inhibition of HbS Polymerization in Sickle Cell Disease.

Sickle cell disease (SCD), a monogenic disorder arising from a single point mutation in the β-globin gene, continues to pose a significant global heal...

"Comprehensive multi-omics of age-respective plasma and matrix-bound extracellular vesicles identifies anti-fibrotic miRNAs validated on a heart-on-a-chip".

Aging is a major risk factor for cardiovascular disease, the leading cause of death worldwide, and numerous other diseases, but the mechanisms of thes...

Organ preservation in rectal cancer: an endoscopist's perspective on current evidence and future directions.

Rectal cancer management has increasingly shifted toward organ-preserving strategies that aim to maintain oncologic control while preserving bowel, ur...

Forecasting Waitlist Trajectories for Patients With Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis: A Neural Network Competing Risk Analysis.

BACKGROUND: Metabolic dysfunction-associated steatohepatitis (MASH) cirrhosis is a leading indication for liver transplantation (LT). Patients with MA...

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson's disease.

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD) and often increase kinase a...

Radiomics-based gradient boosting model on contrast-enhanced MRI for non-invasive prediction of epidermal growth factor receptor expression and therapeutic response to EGFR-targeted antibody-drug conjugates in high-grade glioma organoid models.

BACKGROUND: Epidermal growth factor (EGF) and its receptor EGF(EGFR) play crucial roles in glioblastoma (GBM) prognosis. However, non-invasive assessm...

Data-Integrated Elucidation of Structure-Activity Relationships toward the Rational Design of Perfluoroiodoarene-Based Halogen-Bond Donor Catalysts.

Understanding and predicting catalyst performance from structural and electronic information remains a central challenge in organocatalysis. Here, we ...

Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases.

Aging and age-related diseases are a major public health concern, driving interest in anti-aging research. While small molecules and natural compounds...