Transplantation

Latest AI and machine learning research in transplantation for healthcare professionals.

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Highlights from the Italian National Congress of Imaging in Pulmonology 2025: fostering implementation of advanced technologies for precision patient-centered care.

The Italian National Congress of Imaging in Pulmonology, held in Milan on November 21st, provided a unique educational platform exploring the evolving role of thoracic imaging in respiratory medicine. Organized by the Italian Respiratory Society (SIP-IRS) Imaging Study Group, the congress brought together over 160 participants, including pulmonologists, radiologists, interventional specialists, an...

Mar 5 2026 41784445

Decoding the Glioblastoma Microenvironment: AI-Driven Analysis of Cellular MRI Signatures for Targeted Therapy.

Glioblastoma (GB), the most aggressive primary brain tumor, is characterized by profound inter- and intratumoral heterogeneity and a highly immunosuppressive tumor microenvironment (TME), both of which contribute to its poor prognosis and resistance to conventional therapies. The dynamic interplay between malignant cells and diverse TME constituents including immune cells, neural elements, and ext...

Mar 5 2026 41784819
Harnessing the gut-heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies.

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide despite major advances in pharmacotherapy. Emerging evidence reveals a p...

Mar 4 2026 41791695
Challenges and advances in drug resistance and tolerance in cancer.

Therapeutic resistance remains the principal barrier to durable clinical benefit in oncology, particularly in oncogene-driven malignancies and immune-...

Mar 4 2026 41776655
Impact of Deep Learning-Based Time-of-Flight PET Images of Small Tumors Using a Human Anatomic Phantom.

Time-of-flight (ToF) in PET improves image quality by enhancing the signal-to-noise ratio, and recent deep learning (DL)-based ToF (DL-ToF) methods fu...

Mar 4 2026 41188046
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro.

The lymphatic system-integral to fluid balance, immune surveillance, and lipid absorption-is frequently overlooked despite its vital roles. Traditiona...

Mar 4 2026 41498589
In-Pocket 3D Graphs Enhance Ligand-Target Compatibility in Generative Small-Molecule Creation: A Dopamine D2 Receptor Model System.

Proteins in complex with small-molecule ligands represent the core of structure-based drug discovery. However, three-dimensional representations are a...

Mar 4 2026 41778750
STAND-Net: A Spiking Temporal Attention autoeNcoDer Network for Efficient EEG Artifact Removal.

Electroencephalography (EEG)-based brain computer interface (BCI) systems hold significant promise across diverse applications; however, their perform...

Mar 4 2026 41779656
Explainable machine learning with routine biomarkers identifies culture-defined bacteremic urosepsis.

Urosepsis is a severe complication of urinary tract infection (UTI) and may lead to organ dysfunction and death. Early identification remains challeng...

Mar 4 2026 41781502
Cell-free chromatin state tracing reveals disease origin and therapy responses.

Cell-free DNA in blood originates from fragmented chromatin released by dying cells from both healthy and diseased tissues1,2. These fragments carry r...

Mar 4 2026 41781618
Natural language processing of biomedical text to map and prioritize protein-disease associations in HFpEF.

The validation of promising clinical biomarkers, molecular mechanisms, and novel drug targets in cardiovascular disease (CVD) is hindered by a vast an...

Mar 3 2026 41780317
GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma.

Despite the increasing recognition of pyroptosis, particularly that involving GSDME, its precise impact on tumor prognosis and the immune microenviron...

Mar 3 2026 41776083
Integrative multi-omics analysis reveals metabolic dysfunction signatures as critical determinants of prostate cancer prognosis and immunosuppressive microenvironments.

BACKGROUND: Metabolic reprogramming is a hallmark of cancer. However, the precise mechanisms by which specific metabolic pathways drive prostate cance...

Mar 3 2026 41776615
Development and explainable AI-driven characterization of a prognostic model for haploidentical transplantation outcomes.

We developed a novel, explainable artificial intelligence (AI)-driven prognostic model using a contemporary single-centre cohort of 668 patients under...

Mar 3 2026 41772139
Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma.

Hepatocellular carcinoma remains a leading cause of cancer mortality worldwide, with peritumoral microenvironment interactions playing a critical role...

Mar 2 2026 41780844
Application of a Natural Language Processing Framework for Data Extraction From Pathology Reports Across Multiple Cancer Types.

BACKGROUND: Pathological reports provide comprehensive insights into the clinical and pathological features of different cancer types. However, extrac...

Mar 2 2026 41775279
Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.

UNLABELLED: Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In thi...

Mar 2 2026 41418101
A Native Strategy for Integrating Deep-Learning Models for Segmentation into a Radiological Viewer.

The use of deep-learning (DL) models to support and automate medical imaging diagnostic procedures has become an ongoing focus of research and develop...

Mar 2 2026 41772359
Evaluation of the Effectiveness of an AI-assisted, Dual-Template Workflow in Improving the Accuracy of Tooth Autotransplantation.

OBJECTIVE: To test whether an AI-assisted, dual-template workflow improves plan-delivery accuracy in tooth autotransplantation versus a replica-only f...

Mar 1 2026 41771190
Quantitative CT and Artificial Intelligence in Chronic Lung Disease.

Computed tomography (CT) is routinely used in diagnosing and managing patients with chronic lung diseases such as chronic obstructive pulmonary diseas...

Mar 1 2026 41417666
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