Transplantation

Latest AI and machine learning research in transplantation for healthcare professionals.

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Enhanced bi-branch deep learning network for in vivo hyperspectral imaging recognition of organs and tissues.

Hyperspectral imaging, as an emerging medical imaging technology, offers significant potential in biomedical research due to its ability in capturing rich spectral information. An enhanced bi-branch network integrating graph convolutional network (GCN) and transformer for hyperspectral image recognition of multiple organs and tissues was developed. GCN is able to extract regional information of sa...

Aug 14 2025 40845607

Chronic Ocular Sequelae of Stevens-Johnson Syndrome: Recent Advances in Understanding of Patho-Physiology and Management.

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions primarily triggered by drugs or infections. Although acute management focuses on systemic stabilization, chronic ocular sequelae remain a significant concern with vision-threatening complications arising in up to 75% of the affected patients. Ocular manifestations range from dry eye d...

Aug 13 2025 40802913
MiR-138 reprograms dental pulp stem cells into GABAergic neurons via the GATAD2B/MTA3/WNTs axis for stroke treatment.

Prolonged periods of ischemia and hypoxia pose significant challenges to exogenous stem cell transplantation, including minimal cell survival, varied ...

Aug 8 2025 40803231
Modulating the oral microbiome with dental biomaterials: A review of challenges, advances, and future perspectives.

The oral microbiome plays a pivotal role in maintaining both oral and systemic health. Recent studies highlight the potential of dental biomaterials t...

Aug 7 2025 40815896
Evaluating Dynamic Smile Outcomes of Free Gracilis Muscle Transfer in Pediatric Facial Palsy Using Image-Based Analysis.

BACKGROUND: Facial nerve palsy in children leads to significant functional impairment and facial asymmetry. While free gracilis muscle transfer (FGMT)...

Jul 30 2025 40738135
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering.

Covering: up to 2025.Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and...

Jul 28 2025 40719200
Synergistic innovation in organ-on-a-chip and organoid technologies: Reshaping the future of disease modeling, drug development and precision medicine.

FDA issued guidance on April 10th, 2025 to phase out animal trials in favor of organoids and organ-on-a-chip systems. This pivotal move was swiftly fo...

Jul 13 2025 40653861
Predictors of frontline doublet or triplet regimen initiation in transplant-ineligible newly diagnosed multiple myeloma.

AIMS: To identify predictors for initiation of frontline doublet versus triplet therapy for transplant-ineligible newly diagnosed multiple myeloma.

Jul 12 2025 40650954
Machine learning-based risk prediction model for central nervous system involvement in diffuse large B-cell lymphoma.

Accurate prediction of CNS relapse in DLBCL remains challenging despite existing models like IPI and CNS-IPI. This study aimed to develop a machine le...

Jul 12 2025 40650963
Identification of diagnostic biomarkers and dissecting immune microenvironment with crosstalk genes in the POAG and COVID-19 nexus.

An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms rem...

Jul 12 2025 40652070
Liver Retransplantation: Identifying Factors and Developing a Risk Prediction Model to Predict Futility in the Modern Era.

BACKGROUND: Liver retransplantation (rLT) results have traditionally been inferior compared with those of primary liver transplantation. Understanding...

Jul 11 2025 40644633
Machine learning-assisted assessment of extracellular vesicles can monitor cellular rejection after heart transplant.

BACKGROUND: Heart transplant rejection, particularly acute cellular rejection (ACR), remains a critical post-operative concern, despite declining inci...

Jul 11 2025 40640467
In-silico CT simulations of deep learning generated heterogeneous phantoms.

Current virtual imaging phantoms primarily emphasize geometric accuracy of anatomical structures. However, to enhance realism, it is also important to...

Jul 10 2025 40587975
Comprehensive multi-omics and machine learning framework for glioma subtyping and precision therapeutics.

Glioma is a highly heterogeneous and aggressive brain tumour that demands an integrated understanding of its molecular and immunological landscape. We...

Jul 10 2025 40640380
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML.

Given the graft-versus-leukemia effect observed with allogeneic hematopoietic stem cell transplantation in refractory or relapsed acute myeloid leukem...

Jul 9 2025 40632867
Computation strategies and clinical applications in neoantigen discovery towards precision cancer immunotherapy.

Neoantigens, which are tumor-specific peptides generated by malignant cells, can be presented to T cells to elicit immune responses. Owing to their tu...

Jul 9 2025 40629481
Applying deep learning techniques to identify tonsilloliths in panoramic radiography.

Tonsilloliths can be seen on panoramic radiographs (PRs) as deposits located on the middle portion of the ramus of the mandible. Although tonsillolith...

Jul 9 2025 40634633
Validation of the Toronto recurrence inference using machine-learning for post-transplant hepatocellular carcinoma model.

BACKGROUND: Organ shortages require prioritizing hepatocellular carcinoma (HCC) patients with the highest survival benefit for allografts. While tradi...

Jul 9 2025 40629061
An intelligent tactile imaging-recognition sensor system enabled a methoxynitrobenzene-salicylaldehyde fluorescent material.

Tactile sensors utilizing functional materials decode surface textures for object recognition. Herein, we engineer a donor-acceptor fluorescent materi...

Jul 8 2025 40626524
Evaluating Mandarin tone pronunciation accuracy for second language learners using a ResNet-based Siamese network.

Evaluating tone pronunciation is essential for helping second-language (L2) learners master the intricate nuances of Mandarin tones. This article intr...

Jul 8 2025 40628799
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