Transplantation

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).

Skeletal muscle functions as an endocrine organ, secreting myokines that mediate interorgan communication with bone. Exercise‑induced myokines regulate bone homeostasis by orchestrating osteoblast differentiation, osteoclastogenesis, and osteocyte mechano‑sensing through key signaling pathways, including the Wnt/β‑catenin, mitogen‑activated protein kinase, phosphatidylinositol‑3‑kinase/AKT, nuclea...

Genomic scale analysis of assembly-line polyketide synthase diversity and evolution.

Covering: up to 2026Assembly-line polyketide synthases (PKSs) are among the most sophisticated catalysts in nature, responsible for the biosynthesis of many medicinally important natural products including antibiotics, anticancer agents, immunosuppressants and veterinary agents. While conventional methods for polyketide natural product discovery have fallen out of favor, the rapid expansion of mic...

Multidrug resistance in cancer: current understandings and future perspective.

Multidrug resistance (MDR) remains the core clinical barrier limiting the achievement of durable and effective treatment for various tumors. With the ...

Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer.

BACKGROUND: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain lar...

[Point-of-care biomarkers of ocular surface disease: Current approaches and future perspectives].

Dry eye disease is a common multifactorial condition that significantly impairs patients' quality of life. In clinical practice, conventional diagnost...

Ensemble machine learning for predicting flexural capacity of FRCM-strengthened RC beams.

Fabric reinforced cementitious matrix (FRCM) composites are progressively applied to strengthen reinforced concrete (RC) members because they offer im...

Decoding splicing variants in high-throughput sequencing: a functional validation approach integrating deep learning tools.

High-throughput genome and exome sequencing have uncovered numerous intronic variants in disease genes, yet predicting their impact on pre-mRNA splici...

Immunosuppressive regimens and long-term kidney transplant outcomes: A dual survival modeling framework.

Optimizing immunosuppressive therapy remains central to improving long-term outcomes after kidney transplantation. Both induction and maintenance ther...

Integrated single-cell RNA sequencing and Bulk-RNA technologies reveal the immunological characteristics of lactylation related-genes in glioblastoma.

OBJECTIVE: Glioblastoma (GBM) is the most aggressive type of intracranial malignant tumor, known for its extremely poor prognosis. Lactylation, a newl...

Data-driven design of hybrid graphene oxide-MXene polymeric membranes for water purification.

Two-dimensional (2D) materials offer promising platforms for water purification, particularly for challenging oil-in-water emulsions. Here, a hybrid m...

A novel model (SED-GNDE) integrating graph neural differential equations with selective electrodialysis process for nutrient prediction from synthetic wastewater.

Selective electrodialysis (SED) is a promising method for recovering nutrient ions, such as phosphate, ammonium, sulfate and potassium, from wastewate...

Microfluidic-electrochemical sweat patches for athletes: monitoring lactate, electrolytes, and hydration status.

Wearable biochemical sensing is shifting sports physiology from intermittent laboratory sampling toward continuous, in situ readouts during training a...

AneuSI: A software tool to isolate a region of interest in cerebral aneurysms from full geometrical models.

BACKGROUND AND OBJECTIVE: Modeling cerebral aneurysms using patient-specific geometries demands significant computational resources, particularly when...

Integrative network toxicology, multiomics, and machine learning elucidate zearalenone-induced developmental toxicity mechanisms in zebrafish (Danio rerio).

Zearalenone (ZEN) is a naturally occurring environmental contaminant that is produced by fungi. Developing animals are particularly sensitive to ZEN, ...

IL4Rα blockade inhibits proliferation of malignant lymphocytes and the immunosuppressive tumor microenvironment of mycosis fungoides.

BACKGROUND: Limited therapeutic options are available for patients with advanced-stage mycosis fungoides (MF), and the 5-year survival rate is 25%. Du...

Roles and applications of artificial intelligence in fetal and placental MRI: a literature review.

BACKGROUND: Artificial intelligence (AI) has been increasingly integrated with fetal and placental magnetic resonance imaging (MRI) to enhance the det...

Predicting heterosexual reactions to coming out in China.

For many Chinese sexual minority men, coming out-disclosing their sexual orientation-is stressful because of concerns about how heterosexual recipient...

Impact on Cost and Expert Time of Data-Efficient Deep Learning for Medical Image Segmentation.

Purpose To develop and systematically evaluate an iterative training approach, termed the expert-guided annotation loop, for efficient reference stand...

Segmenting Older Adults by Their Acceptance of Digital Health Care Devices: Cross-Sectional Study Using the Augmented Technology Acceptance Model and K-Means Clustering.

BACKGROUND: Population aging has become a critical global challenge, with South Korea entering a super-aged society and facing rapidly increasing heal...

Human donor liver viability evaluation with polarization-sensitive optical coherence tomography.

Human liver transplantation is constrained by a critical shortage of viable donor livers. In response to this shortage, marginal livers from extended ...