Transplantation

Point-of-care detection for respiratory diseases: From samples and biomarkers to principles and applications.

Early screening can significantly reduce the severe morbidity and mortality of respiratory diseases and alleviate the burden on public healthcare systems. Point-of-care (POC) devices refer to portable instruments that meet the REASSURED criteria and can be conveniently used near the patient without professional laboratory conditions. POC devices played an important role in patient initiated early ...

Nature-inspired macrocyclic peptides: Discovery and molecular engineering for drug development.

Natural cyclic peptides have long served as a rich reservoir of bioactivity, occupying a unique region of the drug space that bridges the gap between small molecules and large biologics. Evolution has perfected the macrocyclic architecture to achieve exceptional target specificity and metabolic stability, providing a structural blueprint that allows these molecules to engage extended protein surfa...

A polyline searching-driven evolutionary AI for disease detection of medical imaging data.

Objective Accurate Ultrasound (US) prostate cancer (PCa) segmentation images hold significant value for organ interventional guidance and clinical...

Predicting Intratumoral Heterogeneity and Stratifying Prognostic Risk in Gastric Cancer Using a Histology-Based Pathomics-Deep Learning Fusion Model.

Intratumoral heterogeneity (ITH) is a fundamental driver of clonal evolution and therapeutic resistance in gastric cancer (GC). However, the clinical ...

Idiopathic inflammatory myopathies as a damage-data-endotype continuum: A roadmap to precision trials and computable biomarkers.

Idiopathic inflammatory myopathies (IIM) are heterogeneous immune-mediated diseases characterized by muscle inflammation that coexists with variable t...

Machine-Learning Versus Traditional Scores for Predicting Outcomes After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-Analysis.

BackgroundCoronary artery bypass grafting (CABG) is associated with significant morbidity and mortality. Traditional risk scores, such as the Society ...

Progress and Perspectives of Furanone Derivatives in Pesticide Chemistry.

Furanone and its derivatives, featuring five-membered oxygen-containing heterocyclic rings, offer broad-spectrum bioactivities and favorable environme...

Prognostic risk modeling based on integrated multi-omics analysis identifies CRY2 as a key regulator in tumor immunity and patient survival in colorectal cancer.

BACKGROUND: Colorectal cancer (CRC) exhibits substantial metabolic heterogeneity. This study developed a robust prognostic signature integrating ferro...

Beyond the guidelines: Vascular function as the central determinant and therapeutic target in hypertension.

Hypertension has traditionally been defined and managed according to brachial blood pressure levels. Although this pressure-centric strategy has signi...

Wood-Inspired Bioadaptable Material with Neurite Outgrowth Guidance Structures, Superior Cell Microenvironment, and Long-Term Structural Stability.

Nerve injuries present serious clinical challenges worldwide. Autologous nerve transplantation is recognized as the gold standard to treat long-gap pe...

From prediction to practice: Barriers to implementing artificial intelligence in blood inventory management and transfusion support.

BACKGROUND: Artificial intelligence (AI) is increasingly applied to blood-demand forecasting, donor management, inventory optimisation, wastage reduct...

Serum Receptor-Interacting Protein Kinase 3 (RIPK3) Is Associated with Transplant-Free Survival in Acute Liver Failure.

BACKGROUND AND AIMS: Prognostication in acute liver failure (ALF) due to acetaminophen (APAP) and other causes of drug-induced liver injury (DILI) rem...

Engineering Organoid Platforms for Pathogenesis Research.

Emerging and re-emerging infectious diseases ranging from the 1918 H1N1 influenza pandemic to the recent SARS-CoV-2 and monkeypox virus outbreaks cont...

Bo-Net: Deep learning-based model for automatic bone stromal cell segmentation of fluorescence microscopy images.

BACKGROUND AND OBJECTIVES: Bone is a multicellular organ that is the site of complex pathophysiological events (such as cancer). 3D confocal and multi...

Stochastic sampling via synaptic delay in spiking RBMs using integrated resistive and threshold switching devices.

Spiking neural networks (SNNs) have emerged as promising low-power architectures for next-generation neuromorphic hardware because spike-based operati...

Sensitive detection of unopposed estrogen using estrogen receptor functionalized nanoprobes for cancer diagnosis.

Unopposed estrogen refers to prolonged estrogenic stimulation in the absence of adequate progesterone-mediated counter-regulation. Unopposed estrogen ...

Deep learning-supported image quantification of epithelial cell shapes and its application to polycystic kidney disease.

Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and apical junctio...

CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.

AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, extensive perineural invasion (PNI), ...

Optimizing Cancer Drug Treatments Using Big Data Integration of Genomic and Clinical Data for Personalized Medicine.

Personalized cancer care depends on the seamless integration of genetic profiles, medical histories, and continuous patient monitoring to optimize the...

Infrared spectroscopy-based chemometric modeling for monitoring mesenchymal stem cell functional decline across donors.

Reliable assessment of cellular state remains a challenge in cell therapy manufacturing and regenerative medicine. Proliferative capacity, senescence,...