Universal precautions

Landslide detection in remote sensing images on the basis of feature recursion and sample balance.

To increase the accuracy of landslide identification via high-resolution optical remote sensing images, this paper presents an improved landslide identification model based on the Mask R-CNN. First, a novel feature image extraction and fusion structure, ResNeSt-RFP, is constructed to enhance the model's capacity for deep landslide feature expression. Second, the improved model incorporates a one-s...

[Chinese guideline for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2026 edition): protocol].

This document serves as the protocol for the development of the Chinese Guideline for the Diagnosis and Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia in Adults (2026 Edition). Since the publication of the previous edition in 2018, the field of HAP/VAP diagnosis and treatment in China has undergone substantial changes, including updates in prevention concepts and meas...

Genotypic-phenotypic concordance of Pasteurella multocida isolated from bovine respiratory disease cases.

Pasteurella multocida is a respiratory pathogen that is frequently isolated from cattle suffering from bovine respiratory disease (BRD), a leading cau...

MXene-Configured Intelligent Mask for Long-Term Sleep Breathing Assessment during Assisted Ventilation.

Positive airway pressure therapy serves as a core therapeutic strategy for sleep-disordered breathing, with its efficacy generally evaluated via sleep...

Integrated deep learning and multi-scale modeling for the discovery of pan-genotypic HCV NS5B polymerase inhibitors.

Chronic Hepatitis C Virus (HCV) infection remains a significant global health challenge, necessitating the development of pan-genotypic inhibitors to ...

Modeling multidimensional perceived risk in HIV-related social media: a multi-label transformers framework with longitudinal analysis.

This paper presents a supervised multi-label framework for detecting multidimensional perceived risk in HIV-related Reddit discourse. A longitudinal c...

RRM2B is associated with low-level viremia during entecavir therapy in pediatric chronic hepatitis B and promotes profibrotic signaling in vitro.

BACKGROUND: Low-level viremia (LLV) during nucleos(t)ide analogue therapy for chronic hepatitis B (CHB) is clinically relevant, but its biological bas...

Bionic Magnetic Nanorobots Combined with AI-Assisted Microscopic Imaging for Argonaute-Powered Multiplexed Foodborne Pathogens Detection.

Multiplexed and ultrasensitive identification of foodborne pathogens is crucial for food safety. However, conventional methods are limited by complex ...

CT-based Deep Learning Model for Automatic Segmentation and Early Predicting of Pyogenic Liver Abscess Caused by Extended-Spectrum β-lactamase-Producing Enterobacteriaceae: A Multicenter Retrospective Study (CLASS2401).

RATIONALE AND OBJECTIVE: Pyogenic liver abscess (PLA) caused by extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PLA) presents major a...

Development of an expert-annotated chest X-ray dataset to support AI validation in tuberculosis diagnosis.

OBJECTIVES: To assess inter-rater agreement and diagnostic performance of six United States National Institute for Occupational Safety and Health-cert...

A machine learning-driven multitask framework for antibiotic resistance prediction in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae bloodstream infections among hematological malignancy patients.

BACKGROUND: Inappropriate empirical antimicrobial therapy (IEAT) significantly increases mortality in patients with resistant Gram-negative bacteremia...

Identification of key genes associated with T cell exhaustion in HIV infection based on transcriptomic data.

BACKGROUND: Human immunodeficiency virus (HIV) is a lentivirus belonging to the retrovirus subclass. HIV specifically targets and infects human CD4 + ...

Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic ...

Plant Biofactories for Vaccination: Progress in Edible Vaccine Technologies as a Sustainable Approach to Global Immunization.

Globally, the pathogen-driven enteric diseases remain a leading cause of morbidity and mortality, disproportionately affecting populations in low-inco...

Virus infections and cancers: from mechanisms to therapeutics.

Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, car...

Ecological and dietary strategies to constrain Clostridioides difficile.

Clostridioides difficile exemplifies a pathogen that leverages its metabolic plasticity to exploit nutrients that become available during community di...

Artificial intelligence for predicting antiretroviral therapy outcomes in people living with HIV: A systematic review of predictive models, predictors and clinical readiness.

BACKGROUND: Machine learning (ML), deep learning (DL) and other predictive modelling approaches are increasingly applied to predict antiretroviral the...

Bioactive environments to combat antimicrobial resistance: artificial intelligence and model-driven microbial biocontrol for living materials.

Antimicrobial resistance (AMR) continues to outpace development of new therapeutics. Many interventions focus on treating infection after it occurs, b...

TACTIC: A transfer learning framework to predict drug interactions in emerging pathogens.

Machine learning (ML) is necessary to efficiently identify potent drug combinations within a large candidate space to combat drug resistance. However,...

Pangenome-guided immunoinformatics design and in silico characterization of a multi-epitope vaccine candidate against Acinetobacter baumannii with nanoparticle assembly potential.

Acinetobacter baumannii is a critical multidrug-resistant pathogen causing severe healthcare infections with high mortality, yet no licensed vaccine e...