Urology

Latest AI and machine learning research in urology for healthcare professionals.

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Single-cell foundation models reveal context-sensitive cancer programmes under subtype shift

Single-cell foundation models (scFMs) have shown promise as transferable representations of cellular state, but recent zero-shot evaluations suggest that they do not consistently outperform simpler baselines. We asked whether this apparent limitation reflects an intrinsic weakness of scFMs or instead the difficulty of using them without task-specific adaptation. To test this, we fine-tuned two wid...

Auditing What Was Said: The Epistemic Promise and Limits of Ambient AI in Clinical Practice

Traditional audit methods that rely on written records often miss the nuances of clinical reasoning that influence patient care. Ambient artificial intelligence captures spoken clinical encounters, allowing the analysis of real clinicianpatient dialogue at scale. In a study of 124 urology consultations, a transcript-centered audit identified inter physician variation and expert disagreement that c...

HF-125, a first-in-class computer-modeled novel inhibitor of Tribbles 2, for therapy of enzalutamide resistant, neuroendocrine prostate cancer.

Second generation antiandrogens, such as enzalutamide, are commonly prescribed to treat advanced prostate cancer. However, enzalutamide resistant pros...

Echo-α: Large Agentic Multimodal Reasoning Model for Ultrasound Interpretation

Ultrasound interpretation requires both precise lesion localization and holistic clinical reasoning, yet existing methods typically excel at only one ...

Apr 30 2026 2604.28011v1
SAMe: A Semantic Anatomy Mapping Engine for Robotic Ultrasound

Robotic ultrasound has advanced local image-driven control, contact regulation, and view optimization, yet current systems lack the anatomical underst...

Apr 28 2026 2604.25646v1
Exposome-Based Clustering of Urinary VOC and PAH Biomarkers Reveals Racially Patterned Cardiovascular Risk in a Nationally Representative US Cohort: A Machine Learning Analysis of NHANES 2017-2018

Background Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) are combustion-derived pollutants linked to cardiovascular di...

CMGL: Confidence-guided Multi-omics Graph Learning for Cancer Subtype Classification

Motivation: Multi-omics integration can improve cancer subtyping, but modality informativeness and noise vary across cancer types and patients. Existi...

Apr 27 2026 2604.24201v1
Dialysis Risk Prediction and Treatment Effect Estimation for AKI patients using Longitudinal Electronic Health Records

Progression to dialysis or end-stage renal disease is a rare but clinically important outcome. Clinicians need evidence on how medication exposures in...

Apr 27 2026 2604.24547v1
Multi-Modal Deep Learning Integrates Spatial Topologies and Sequential Motifs to Identify Class I HDAC Inhibitors as Pan-Cancer Therapeutics

The molecular characterization of human solid growths has introduced immense genomic complexity and intra-tumoral diversification. Converting these de...

HFS-TriNet: A Three-Branch Collaborative Feature Learning Network for Prostate Cancer Classification from TRUS Videos

Transrectal ultrasound (TRUS) imaging is a cost-effective and non-invasive modality widely used in the diagnosis of prostate cancer. The computer-aide...

Apr 24 2026 2604.22388v1
Comparing Gleason Pattern 4 Measurement Approaches on Prostate Biopsy Using Machine Learning: A Proof-of-Principle Study

Objective: To demonstrate the proof of principle that machine learning (ML) can be used to quantify Gleason Pattern (GP) 4 on digitized biopsy slides ...

CohortContrast: An R Package for Enrichment-Based Identification of Clinically Relevant Concepts in OMOP CDM Data

Abstract Objective To address the unresolved bottleneck of selecting cohort-relevant clinical concepts for treatment trajectory analysis in observatio...

Accessible and Reproducible Renal Cell Carcinoma Research Through Open-Sourcing Data and Annotations

Background: Medical imaging, especially computed tomography and magnetic resonance imaging, is essential in clinical care of patients with renal cell ...

Causal-Transformer with Adaptive Mutation-Locking for Early Prediction of Acute Kidney Injury

Accurate early prediction of Acute Kidney Injury (AKI) is critical for timely clinical intervention. However, existing deep learning models struggle w...

Apr 22 2026 2604.20259v1
Preoperative CT-Based Habitat Radiomics Classifiers Predict Recurrence in Non-Small Cell Lung Cancer

Objectives: Among surgically resected non-small cell lung cancer (NSCLC) patients with similar stage and histopathological characteristics, there is v...

Design Space Exploration of Hybrid Quantum Neural Networks for Chronic Kidney Disease

Hybrid Quantum Neural Networks (HQNNs) have recently emerged as a promising paradigm for near-term quantum machine learning. However, their practical ...

Apr 15 2026 2604.13608v1
Integrated kidney and urine proteomics define encrypted antimicrobial peptides as effectors of host defence in human pyelonephritis

Antimicrobial peptides (AMPs) are key effectors of host defence, however, their functional deployment across renal tissue and urine in pyelonephritis ...

Risk-Calibrated Learning: Minimizing Fatal Errors in Medical AI

Deep learning models often achieve expert-level accuracy in medical image classification but suffer from a critical flaw: semantic incoherence. These ...

Apr 14 2026 2604.12693v1
DoseRAD2026 Challenge dataset: AI accelerated photon and proton dose calculation for radiotherapy

Purpose: Accurate dose calculation is essential in radiotherapy for precise tumor irradiation while sparing healthy tissue. With the growing adoption ...

Apr 14 2026 2604.12778v1
OpenTME: An Open Dataset of AI-powered H&E Tumor Microenvironment Profiles from TCGA

The tumor microenvironment (TME) plays a central role in cancer progression, treatment response, and patient outcomes, yet large-scale, consistent, an...

Apr 13 2026 2604.12075v1
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