Urology

Latest AI and machine learning research in urology for healthcare professionals.

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Machine Learning-Driven Assessment of Early Graft Function in Living Donor Kidney Transplantation Using Intraoperative Laser Speckle Contrast Imaging

Although living donor kidney transplantation (LDKT) generally achieves excellent outcomes, 5–12% of recipients experience early graft dysfunction, which is associated with poorer long-term survival. Current predictive tools rely mainly on clinical parameters and lack intraoperative applicability. Laser speckle contrast imaging (LSCI) enables real-time, non-contact assessment of renal microcirculat...

Validation of virtual trichrome stains for kidney fibrosis evaluation using dual-mode emission and transmission microscopy

Assessment of interstitial fibrosis is essential in the diagnosis and prognosis of kidney diseases. However, current histologic scoring methods using trichrome-stained slides are limited by inter-observer variability and inconsistent stain reproducibility. To address these challenges, we developed DUET (DUal-mode Emission and Transmission) microscopy, a novel imaging platform that rapidly captures...

Quantum Dot Encoding for In-Solution Single-Molecule Biomarker Counting in Metastatic Prostate Cancer

Digital assays are in wide development for biomarker quantification at the single-molecule level, but the common use of surface-pulldown steps limits ...

Metformin use is associated with lower mortality from bacterial sepsis and improved immunocompetence in Thai diabetes patients with acute melioidosis

Diabetes mellitus (DM) is a major risk factor for acquiring infections. Metformin, the first-line treatment for type 2 DM, is associated with benefici...

Using routine laboratory tests to perform early prediction of urine culture results

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, typically diagnosed using a urine culture. However, urine cu...

Radiologic, Pathologic, and Deep Learning Predictors of Response to Immune Checkpoint Blockade in Renal Cell Carcinoma Patients Undergoing Post-Treatment Nephrectomy

Response assessment of primary kidney tumors in the consolidation cytoreductive and neoadjuvant settings offers a unique opportunity to inform postope...

Causal modeling of chronic kidney disease in a participatory framework for informing the inclusion of social drivers in health algorithms

Incomplete or incorrect causal theories are a key source of bias in machine learning (ML) algorithms. Community-engaged methodologies provide an avenu...

Discrete-Event Simulation Modeling Framework for Cancer Interventions and Population Health in R (DESCIPHR): An Open-Source Pipeline

Simulation models inform health policy decisions by integrating data from multiple sources and forecasting outcomes when there is a lack of comprehens...

Assessment of HeartModelĀ® Automated Left Ventricular Ejection Fraction for Patients with Hypertrophic Cardiomyopathy

Cardiac myosin inhibitors (CMIs) have revolutionized care for patients with obstructive hypertrophic cardiomyopathy (HCM), however they are associated...

Enhancing Anterior Quadratus Lumborum Block Accuracy with Artificial Intelligence: A Segmentation Approach Evaluated by Dice Score Metrics

Anterior quadratus lumborum (QL) block is a regional anesthesia technique shown to provide both somatic and visceral pain relief by targeting lower th...

Development of an LLM Pipeline Surpassing Physicians in Cardiovascular Risk Score Calculation

Risk scores are essential to evidence-based cardiovascular care, but manual calculation is labor-intensive and error-prone. Large language models (LLM...

Development and validation of Retrieval Augmented Generation (RAG) and GraphRAG for complex clinical cases

Chronic Kidney Disease (CKD) is a progressive condition requiring evidence-based management, but adherence to complex guidelines remains challenging. ...

Characterize Disease Progression Subphenotypes in Real World Populations with Overweight and Obesity using a Graph-based Neural Network Framework

Obesity is a chronic, heterogeneous condition, with risks, trajectories, and treatment responses that vary widely among individuals. However, research...

Improving automated prostate pathological grading via confidence filtering

There have been many promising developments in deep learning to identify degrees of malignancies in prostate cancer pathologies. Deep network models h...

Does LLM Assistance Improve Healthcare Delivery? An Evaluation Using On-site Physicians and Laboratory Testsāˆ—

We deployed large language model (LLM) decision support for health workers at two outpatient clinics in Nigeria. For each patient, health workers draf...

When AI Meets the FDA: An Evaluation of Large Language Models Performance in Regulatory and Clinical Trial Data Extraction, Synthesis, and Analysis

Clinical and population decision-making relies on the systematic evaluation of extensive regulatory evidence. The FDA drug reviews provide detailed in...

Precision Immunosuppression and Long-Term Kidney Transplant Outcomes: A Dual Survival Modeling Framework

Optimizing immunosuppressive therapy remains central to improving long-term outcomes after kidney transplantation. Both induction and maintenance ther...

Environmental Chemicals as Modifiers of the Association between Age and Ovarian Reserve

To evaluate whether the well-established age-related reduction in antral follicle counts (AFC) is greater among women with higher concentrations of en...

Clustering high-cost patients in England using machine learning: a population-based cohort study

To identify clusters of high-cost patients in England based on diagnoses and sociodemographic characteristics to inform targeted population health man...

OpenSlideFM: A Computationally Efficient Multi-Scale Foundation Model for Computational Pathology

Computational pathology increasingly relies on foundation models pre-trained on large-scale histopathology datasets, but existing models require subst...

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