Venous Thrombosis

Development of an artificial intelligence-enhanced warfarin interaction checker platform.

Warfarin is a common anticoagulant drug for thrombo-prophylaxis in stroke and venous thromboembolism, which has many advantages but also some disadvantages including narrow therapeutic window, vast drug interactions (and wide variability with foods/herbs), as well as unpredictability of pharmacodynamics and/or kinetics. Complicating factors can present as challenges for the outpatient clinicians t...

Anticoagulation colloidal microrobots based on heparin-mimicking polymers.

Coagulation within blood vessels is a major cause of cardiovascular disease and global mortality, highlighting the urgent need for effective anticoagulant strategies. In this study, we introduce a dynamic and highly efficient anticoagulant platform, achieved through the fabrication of a novel colloidal microrobot with unique functional properties. The microrobot is a Janus colloidal sphere with on...

RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling.

The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate...

Machine Learning Predicts Bleeding Risk in Atrial Fibrillation Patients on Direct Oral Anticoagulant.

Predicting major bleeding in nonvalvular atrial fibrillation (AF) patients on direct oral anticoagulants (DOACs) is crucial for personalized care. Alt...

Utilizing 12-lead electrocardiogram and machine learning to retrospectively estimate and prospectively predict atrial fibrillation and stroke risk.

BACKGROUND: The stroke risk in patients with subclinical atrial fibrillation (AF) is underestimated. By identifying patients at high risk of embolic s...

Causal Machine Learning for Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation.

BACKGROUND: Transcatheter left atrial appendage occlusion (LAAO) is an alternative to lifelong anticoagulation, but optimal patient selection remains ...

Correlation of rivaroxaban solubility in mixed solvents for optimization of solubility using machine learning analysis and validation.

In this study, the solubility of rivaroxaban, a poorly water-soluble drug, was investigated in mixed solvent systems to address challenges in pharmace...

Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer.

BACKGROUND: Gastric cancer patients are prone to lower extremity deep vein thrombosis (DVT) after surgery, which is an important cause of death in pos...

Optimizing warfarin dosing in diabetic patients through BERT model and machine learning techniques.

This study highlights the importance of evaluating warfarin dosing in diabetic patients, who require careful anticoagulation management. With rising r...

Machine learning analysis of rivaroxaban solubility in mixed solvents for application in pharmaceutical crystallization.

This study investigates the use of machine learning models to predict solubility of rivaroxaban in binary solvents based on temperature (T), mass frac...

Machine Learning-Assisted Biomass-Derived Carbon Dots as Fluorescent Sensor Array for Discrimination of Warfarin and Its Metabolites.

Warfarin (WAR), an effective oral anticoagulant, is of utmost importance in treating many diseases. Despite its significance, rapid and precise discri...

Preparation and optimisation of solid lipid nanoparticles of rivaroxaban using artificial neural networks and response surface method.

AIMS: This study aimed to improve rivaroxaban delivery by optimising solid lipid nanoparticles (SLN) for minimal mean diameter and maximal entrapment ...

Innovative modified-net architecture: enhanced segmentation of deep vein thrombosis.

A new era for diagnosing and treating Deep Vein Thrombosis (DVT) relies on precise segmentation from medical images. Our research introduces a novel a...

The predictive value of heparin-binding protein for bacterial infections in patients with severe polytrauma.

INTRODUCTION: Heparin-binding protein is an inflammatory factor with predictive value for sepsis and participates in the inflammatory response through...

Development of Machine-learning Model to Predict Anticoagulant Use and Type in Geriatric Traumatic Brain Injury Using Coagulation Parameters.

This study aimed to investigate the patterns of anticoagulation therapy and coagulation parameters and to develop a prediction model to predict the ty...

Residual risk prediction in anticoagulated patients with atrial fibrillation using machine learning: A report from the GLORIA-AF registry phase II/III.

BACKGROUND: Although oral anticoagulation decreases the risk of thromboembolism in patients with atrial fibrillation (AF), a residual risk of thrombot...

From Code to Clots: Applying Machine Learning to Clinical Aspects of Venous Thromboembolism Prevention, Diagnosis, and Management.

The high incidence of venous thromboembolism (VTE) globally and the morbidity and mortality burden associated with the disease make it a pressing issu...

Heparin in sepsis: current clinical findings and possible mechanisms.

Sepsis is a clinical syndrome resulting from the interaction between coagulation, inflammation, immunity and other systems. Coagulation activation is ...

Radiomics prediction models of left atrial appendage hypercoagulability based on machine learning algorithms: an exploration about cardiac computed tomography angiography imaging.

Transesophageal echocardiography (TEE) is the standard method for diagnosing left atrial appendage (LAA) hypercoagulability in patients with atrial fi...

Prediction model for major bleeding in anticoagulated patients with cancer-associated venous thromboembolism using machine learning and natural language processing.

PURPOSE: We developed a predictive model to assess the risk of major bleeding (MB) within 6 months of primary venous thromboembolism (VTE) in cancer p...