Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Nov 6, 2024
Brain alterations associated with illness severity in schizophrenia remain poorly understood. Establishing linkages between imaging biomarkers and symptom expression may enhance mechanistic understanding of acute psychotic illness. Constructing model...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Jan 11, 2022
Prediction errors (PEs) are a keystone for computational neuroscience. Their association with midbrain neural firing has been confirmed across species and has inspired the construction of artificial intelligence that can outperform humans. However, t...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Nov 11, 2021
Behavioral phenotyping devices have been successfully used to build ethograms, but many aspects of behavior remain out of reach of available phenotyping systems. We now report on a novel device, which consists in an open-field platform resting on hig...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Jul 25, 2020
To study brain function, preclinical research heavily relies on animal monitoring and the subsequent analyses of behavior. Commercial platforms have enabled semi high-throughput behavioral analyses by automating animal tracking, yet they poorly recog...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Jul 17, 2020
The broad adoption and use of smartphones has led to fundamentally new opportunities for capturing social, behavioral, and cognitive phenotypes in free-living settings, outside of research laboratories and clinics. Predicated on the use of existing p...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Jul 15, 2020
Psychiatry today must gain a better understanding of the common and distinct pathophysiological mechanisms underlying psychiatric disorders in order to deliver more effective, person-tailored treatments. To this end, it appears that the analysis of '...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Oct 3, 2019
Patients with schizophrenia (SCZ), as well as their unaffected siblings (SIB), show functional connectivity (FC) alterations during performance of tasks involving attention. As compared with SCZ, these alterations are present in SIB to a lesser exten...