Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: In recent years, the association between metabolites and complex human diseases has increasingly been recognized as a major research focus. Traditional wet-lab experiments are considered time-consuming and labor-intensive, w...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive cognitive decline, necessitating early diagnosis for effective treatment. This study presents the Relational Bi-level Aggregation Graph Convolutional Network with...
Alzheimer's Disease (AD) as one of the most prevalent neurodegenerative disorders worldwide, characterized by significant memory and cognitive decline in its later stages, severely impacting daily lives. Consequently, early diagnosis and accurate ass...
The most prevalent type of dementia and a progressive neurodegenerative disease, Alzheimer's disease has a major influence on day-to-day functioning due to memory loss, cognitive decline, and behavioral problems. By using synchrosqueezing representat...
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Concurrent neurodegenerative and vascular pathologies pose a diagnostic challenge in the clinical setting, with histopathology remaining the definitive modality for dementia-type diagnosis. To address this clinical challenge, we introduce a neuropath...
Positron emission tomography (PET) imaging technology is widely used for diagnosing Alzheimer's disease (AD) in people with dementia. Although various computational methods have been proposed for diagnosis of AD using PET images, prediction of diseas...
Alzheimer's disease (AD) is a progressive neurological disorder characterized by cognitive decline due to brain cell death, typically manifesting later in life.Early and accurate detection is critical for effective disease management and treatment. T...
BACKGROUND: Early identification of individuals who progress from normal cognition (NC) to mild cognitive impairment (MCI) may help prevent cognitive decline. We aimed to build predictive models using radiomic features of the bilateral hippocampus in...
Deformable brain templates are an important tool in many neuroimaging analyses. Conditional templates (e.g., age-specific templates) have advantages over single population templates by enabling improved registration accuracy and capturing common proc...