Journal of chemical information and modeling
Aug 11, 2025
Noncanonical amino acids (NCAAs) occupy an important place, both in natural biology and in synthetic applications. However, modeling these amino acids still lies outside the capabilities of most deep learning methods due to sparse training data sets ...
The pyrrolysyl-tRNA synthetase (PylRS) is widely used to incorporate noncanonical amino acids (ncAAs) into proteins. However, the yields of most ncAA-containing protein remain low due to the limited activity of PylRS variants. Here, we apply machine...
The immune response to tumour development is frequently targeted with therapeutics but remains largely unexplored in diagnostics, despite being stronger for early-stage tumours. We present an immunodiagnostic platform to detect this. We identify a pa...
Soybean is being increasingly included in human diets, highlighting the importance of determining its composition. Although Fourier-Transform Near-Infrared Spectroscopy (FT-NIRS) has become a promising technology, currently used models remain limited...
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Amino acids are crucial nitrogen sources in high-temperature Daqu (HTD), and they can significantly influence the quality of HTD. This study investigated amino acid patterns by analyzing fermentation parameters and microbial communities. Correlation ...
Class Ι major histocompatibility complexes (MHC-Ι), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8-10 amino acids, loaded ...
Regulatory toxicology and pharmacology : RTP
Jun 16, 2025
In the next-generation risk assessment (NGRA) of skin sensitization, estimating the point of departure (PoD) is crucial. The murine local lymph node assay (LLNA) has been considered the 'gold standard' for evaluating the skin sensitizing potential of...
International journal of molecular medicine
Jun 6, 2025
This review delves into the intricate relationship between amino acid metabolism and inflammation in coronary heart disease (CHD). Research shows that disruptions in the metabolism of arginine, glutamate, branched‑chain amino acids (BCAAs) and trypto...
Journal of chemical information and modeling
May 26, 2025
Computational protein design (CPD) refers to the use of computational methods to design proteins. Traditional methods relying on energy functions and heuristic algorithms for sequence design are inefficient and do not meet the demands of the big data...
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