AIMC Topic: Aneuploidy

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How should the best human embryo in vitro be? Current and future challenges for embryo selection.

Minerva obstetrics and gynecology Jun 16, 2023
In-vitro fertilization (IVF) aims at overcoming the causes of infertility and lead to a healthy live birth. To maximize IVF efficiency, it is critical to identify and transfer the most competent embryo within a cohort produced by a couple during a cy...
Fertilization in Vitro Genetic Testing Blastocyst Aneuploidy Humans Artificial Intelligence
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Classifying aneuploidy in genotype intensity data using deep learning.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie Feb 21, 2023
Aneuploidy is the loss or gain of one or more chromosomes. Although it is a rare phenomenon in liveborn individuals, it is observed in livestock breeding populations. These breeding populations are often routinely genotyped and the genotype intensity...
Animals Deep Learning Genotype Neural Networks, Computer Aneuploidy
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Does embryo categorization by existing artificial intelligence, morphokinetic or morphological embryo selection models correlate with blastocyst euploidy rates?

Reproductive biomedicine online Oct 1, 2022
RESEARCH QUESTION: Does embryo categorization by existing artificial intelligence (AI), morphokinetic or morphological embryo selection models correlate with blastocyst euploidy?
Aneuploidy Preimplantation Diagnosis Retrospective Studies Pregnancy Female Adult Embryo Implantation Blastocyst Humans Artificial Intelligence
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An artificial intelligence model correlated with morphological and genetic features of blastocyst quality improves ranking of viable embryos.

Reproductive biomedicine online Aug 3, 2022
RESEARCH QUESTION: Can better methods be developed to evaluate the performance and characteristics of an artificial intelligence model for evaluating the likelihood of clinical pregnancy based on analysis of day-5 blastocyst-stage embryos, such that ...
Retrospective Studies Pregnancy Female Humans Artificial Intelligence Aneuploidy Fertilization in Vitro Embryo Implantation Blastocyst
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Can the combination of time-lapse parameters and clinical features predict embryonic ploidy status or implantation?

Reproductive biomedicine online Jun 17, 2022
RESEARCH QUESTION: Can models based on artificial intelligence predict embryonic ploidy status or implantation potential of euploid transferred embryos? Can the addition of clinical features into time-lapse monitoring (TLM) parameters as input data i...
Aneuploidy Ploidies Time-Lapse Imaging Female Embryo Implantation Blastocyst Preimplantation Diagnosis Humans Artificial Intelligence Retrospective Studies Pregnancy
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For whom the artificial intelligence bell tolls: preimplantation genetic testing for aneuploidy, does it toll for thee?

Fertility and sterility Jan 20, 2022
Genetic Testing Aneuploidy Humans Artificial Intelligence
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Artificial intelligence in the embryology laboratory: a review.

Reproductive biomedicine online Nov 12, 2021
The goal of an IVF cycle is a healthy live-born baby. Despite the many advances in the field of assisted reproductive technologies, accurately predicting the outcome of an IVF cycle has yet to be achieved. One reason for this is the method of selecti...
Live Birth Fertilization in Vitro Aneuploidy Reproductive Techniques, Assisted Pregnancy Humans Female Artificial Intelligence
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End-to-end deep learning for recognition of ploidy status using time-lapse videos.

Journal of assisted reproduction and genetics May 22, 2021
PURPOSE: Our retrospective study is to investigate an end-to-end deep learning model in identifying ploidy status through raw time-lapse video.
Humans Retrospective Studies Female Adult Time-Lapse Imaging Blastocyst Image Processing, Computer-Assisted Deep Learning Aneuploidy Diploidy Fertilization in Vitro Calibration Preimplantation Diagnosis Area Under Curve
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Towards the selection of embryos with the greatest implantation potential.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Jan 12, 2021
Choosing the most suitable embryo remains challenging as the standard approach to select top-quality embryos for transfer rely on static morphological assessment. It is completed after fertilisation, on days 3 and 5 post oocyte retrieval and evaluate...
Chromosome Aberrations Aneuploidy Embryo, Mammalian Embryonic Development Humans Female Artificial Intelligence Fertilization in Vitro Pregnancy Genetic Testing
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A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas.

Scientific reports Jul 16, 2020
Glioblastoma is the most common malignant brain parenchymal tumor yet remains challenging to treat. The current standard of care-resection and chemoradiation-is limited in part due to the genetic heterogeneity of glioblastoma. Previous studies have i...
Image Interpretation, Computer-Assisted Brain Neoplasms Chromosomes, Human, Pair 10 Isocitrate Dehydrogenase Gene Expression Female Chromosomes, Human, Pair 7 Preoperative Care Mutation Sensitivity and Specificity X-linked Nuclear Protein Humans Aneuploidy Biomarkers, Tumor Cyclin-Dependent Kinase Inhibitor p16 Artificial Intelligence Decision Trees Retrospective Studies Glioblastoma Male Magnetic Resonance Imaging
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