Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distribu...
The vast amount of registered chemicals leads to a high diversity of substances occurring in the environment and the creation of new substances outpaces chemical risk assessment as well as monitoring strategies. Hence, risk assessment strategies need...
Neurons in cortical networks are very sparsely connected; even neurons whose axons and dendrites overlap are highly unlikely to form a synaptic connection. What is the relevance of such sparse connectivity for a network's function? Surprisingly, it h...
In this study, count-based Morgan fingerprints (CMF) were employed to represent the fundamental chemical structures of contaminants, and a neural network model (R² = 0.76) was developed to predict acute fish toxicity (AFT) of organic compounds. Model...
The androgen receptor (AR) activation by androgens is vital for tissue development, sexual differentiation, and reproductive attributes in zebrafish (). However, our understanding of the molecular mechanisms behind their activation remains limited. I...
The widespread adoption of deep learning to model neural activity often relies on "black-box" approaches that lack an interpretable connection between neural activity and network parameters. Here, we propose using algorithm unrolling, a method for in...
Langmuir : the ACS journal of surfaces and colloids
Mar 12, 2025
Polymer informatics has attracted increasing attention because machine learning can establish quantitative structure-property relationships in polymer materials. Understanding and controlling protein adsorption on polymer surfaces are crucial for var...
Recalcitrant biofilm infections pose a great challenge to human health. Micro- and nanorobots have been used to eliminate biofilm infections in hard-to-reach regions inside the body. However, applying antibiofilm robots under physiological conditions...
There is great interest in using genetically tractable organisms such as to gain insights into the regulation and function of sleep. However, sleep phenotyping in has largely relied on simple measures of locomotor inactivity. Here, we present FlyVI...
BACKGROUND: Capillariid nematode eggs have been reported in archaeological material in both the New and the Old World, mainly in Europe and South America. They have been found in various types of samples, as coprolites, sediments from latrines, pits,...
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