AIMC Topic: Animals

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The role and future prospects of artificial intelligence algorithms in peptide drug development.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Peptide medications have been more well-known in recent years due to their many benefits, including low side effects, high biological activity, specificity, effectiveness, and so on. Over 100 peptide medications have been introduced to the market to ...

Development and comparison of machine learning models for in-vitro drug permeation prediction from microneedle patch.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
The field of machine learning (ML) is advancing to a larger extent and finding its applications across numerous fields. ML has the potential to optimize the development process of microneedle patch by predicting the drug release pattern prior to its ...

Deep learning generation of preclinical positron emission tomography (PET) images from low-count PET with task-based performance assessment.

Medical physics
BACKGROUND: Preclinical low-count positron emission tomography (LC-PET) imaging offers numerous advantages such as facilitating imaging logistics, enabling longitudinal studies of long- and short-lived isotopes as well as increasing scanner throughpu...

Consistent and effective method to define the mouse estrous cycle stage by a deep learning-based model.

The Journal of endocrinology
The mouse estrous cycle is divided into four stages: proestrus (P), estrus (E), metestrus (M), and diestrus (D). The estrous cycle affects reproductive hormone levels in a wide variety of tissues. Therefore, to obtain reliable results from female mic...

Time series (2003-15) analysis of selected physicochemical parameters in Indian Ocean: Cumulative impacts prediction on coral bleaching using machine learning.

The Science of the total environment
Coral bleaching is an important ecological threat worldwide, as the coral ecosystem supports a rich marine biodiversity to survive. Sea surface temperature was considered a major culprit; however, later it was observed that other water parameters lik...

Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.

Scientific reports
Optical coherence tomography (OCT) is a medical imaging method that generates micron-resolution 3D volumetric images of tissues in-vivo. Photothermal (PT)-OCT is a functional extension of OCT with the potential to provide depth-resolved molecular inf...

Metrisor: A novel diagnostic method for metritis detection in cattle based on machine learning and sensors.

Theriogenology
The Metrisor device has been developed using gas sensors for rapid, highly accurate and effective diagnosis of metritis. 513 cattle uteri were collected from abattoirs and swabs were taken for microbiological testing. The Metrisor device was used to ...

Deep learning models for atypical serotonergic cells recognition.

Journal of neuroscience methods
BACKGROUND: The serotonergic system modulates brain processes via functionally distinct subpopulations of neurons with heterogeneous properties, including their electrophysiological activity. In extracellular recordings, serotonergic neurons to be in...

Source Tracing of Kidney Injury via the Multispectral Fingerprint Identified by Machine Learning-Driven Surface-Enhanced Raman Spectroscopic Analysis.

ACS sensors
Early diagnosis of drug-induced kidney injury (DIKI) is essential for clinical treatment and intervention. However, developing a reliable method to trace kidney injury origins through retrospective studies remains a challenge. In this study, we desig...

Machine-Learning-Aided Understanding of Protein Adsorption on Zwitterionic Polymer Brushes.

ACS applied materials & interfaces
Constructing antifouling surfaces is a crucial technique for optimizing the performance of devices such as water treatment membranes and medical devices in practical environments. These surfaces are achieved by modification with hydrophilic polymers....