Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
International journal of pharmaceutics
Jul 30, 2025
The unpleasant tastes of drugs, including bitterness, pungency, astringency, and sourness, significantly impedes patient adherence, particularly among pediatric and geriatric populations. Accurate evaluation of these tastes is essential for optimizin...
Indentation-based mechanical tests are advantageous for measuring tissue and cell stiffness due to their simplicity and ability to probe samples non-destructively. Most commonly, spherical or pyramidal probes are used, and Hertzian analysis is applie...
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use m...
Brain networks exhibit diverse topological structures to adapt and support brain functions. The changes in neuronal network architecture can lead to alterations in neuronal spiking activity, yet how individual neuronal behavior reflects network struc...
Bronchial foreign body aspiration is a life-threatening condition with a high incidence across diverse populations, requiring urgent diagnosis and treatment. However, the limited availability of skilled practitioners and advanced medical equipment in...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 29, 2025
Accurate wound age estimation is of great significance in forensic practice. However, postmortem changes often obscure or even obliterate the biological information of skeletal muscle injuries, making it extremely challenging to accurately estimate t...
Journal of controlled release : official journal of the Controlled Release Society
Jul 29, 2025
Intervertebral disc degeneration (IVDD) is a primary contributor to the development of low back pain, characterized by core pathological features which include extracellular matrix (ECM) degradation, oxidative stress, imbalanced inflammatory microenv...
BACKGROUND: Heat stress (HS) is a significant challenge in poultry, negatively impacting feed efficiency and survival. These adaptive responses could lead to disrupted lipid metabolism, impaired immunity, and neural damage. We hypothesized that the n...
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