AIMC Topic: Antifungal Agents

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inhibition of biofilm and virulence factor production in azole-resistant strains of isolated from diabetic foot by stabilized tin (IV) oxide nanoparticles.

Frontiers in cellular and infection microbiology
The advent of nanotechnology has been instrumental in the development of new drugs with novel targets. Recently, metallic nanoparticles have emerged as potential candidates to combat the threat of drug-resistant infections. Diabetic foot ulcers (DFUs...

1,3,4-oxadiazole derivatives: synthesis, characterization, antifungal activity, DNA binding investigations, TD-DFT calculations, and molecular modelling.

Journal of biomolecular structure & dynamics
1,3,4-Oxadiazole-based heterocyclic analogs (3a-3m) were synthesized cyclization of Schiff bases with substituted aldehydes in the presence of bromine and acetic acid. The structural clarification of synthesized molecules was carried out with variou...

Coupling machine learning and epidemiological modelling to characterise optimal fungicide doses when fungicide resistance is partial or quantitative.

Journal of the Royal Society, Interface
Increasing fungicide dose tends to lead to better short-term control of plant diseases. However, high doses select more rapidly for fungicide resistant strains, reducing long-term disease control. When resistance is qualitative and complete-i.e. resi...

Impact of ANN in Revealing of Viral Peptides.

BioMed research international
All organisms contain antimicrobial peptides (AMPs), which are a critical component of the innate immune system. These chemicals have the ability to suppress the growth of a variety of fungi, bacteria, and viruses. Because AMPs interact with structur...

Machine learning approach for predicting the antifungal effect of gilaburu (Viburnum opulus) fruit extracts on Fusarium spp. isolated from diseased potato tubers.

Journal of microbiological methods
This work addresses the mathematical model building to detect the diameter of the inhibition zone of gilaburu (Viburnum opulus L.) extract against eight different Fusarium strains isolated from diseased potato tubers. Gilaburu extracts were obtained ...

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.

Nature communications
Fungal pathogens pose a global threat to human health, with Candida albicans among the leading killers. Systematic analysis of essential genes provides a powerful strategy to discover potential antifungal targets. Here, we build a machine learning mo...

Comparison of the Antifungal Efficacy of Four Concentrations of (Muña) Essential Oil against An Study.

The journal of contemporary dental practice
AIM AND OBJECTIVE: This paper aims to compare the antifungal efficacy of four concentrations of essential oil (MEO) against ATCC 10231.

Lemongrass-Incorporated Tissue Conditioner with Adjustable Inhibitory Effect Against Candida albicans: An In Vitro Study.

The International journal of prosthodontics
PURPOSE: To develop and assess lemongrass-incorporated tissue conditioners (LG-TCs) with a potent and long-lasting inhibitory effect against Candida albicans cultures to control the accumulation of fungi.

Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...