Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition that affects a growing number of individuals worldwide. Despite extensive research, the underlying causes of ASD remain largely unknown, with genetic predisposition, parental hi...
BACKGROUND: Large Language Models (LLMs) such as ChatGPT and Google Gemini are increasingly explored for their potential in patient education, particularly in the perioperative setting. As text-based tools trained on extensive datasets, they can gene...
Biomedical physics & engineering express
Nov 19, 2025
Artificial intelligence (AI) systems are increasingly used in medical imaging for disease diagnosis, yet their vulnerability to adversarial attacks poses significant risks for clinical deployment. In this work, we systematically evaluate the suscepti...
Journal of chemical information and modeling
Nov 18, 2025
Neuroscience is the most difficult therapeutic area for pharmaceutical drug discovery. The blood-brain barrier (BBB) prevents ∼100% of large molecules and >98% of small molecules from penetrating the central nervous system (CNS). Most small molecule ...
Journal of chemical information and modeling
Nov 18, 2025
The design of novel molecules underpins advances in both drug discovery and biomaterials engineering. Traditional approaches, from natural product isolation to high-throughput screening, have delivered important therapeutics but remain costly, ineffi...
Phosphodiesterase 4 (PDE4) has been validated as a promising therapeutic target for idiopathic pulmonary fibrosis (IPF), a devastating interstitial lung disease lacking really effective therapeutic drugs, particularly exacerbated in the post-COVID-19...
BACKGROUND: Quantitative kinetic models of biological regulatory processes play an important role in understanding disease mechanisms. However, their simulation and analysis require specialized domain expertise.
Model-informed drug development (MIDD) plays an important role in pharmacometrics by leveraging mathematical models to optimize drug dosing strategies. Traditional methods such as nonlinear mixed effects modeling (NONMEM) have long been the gold stan...
Artificial Intelligence (AI) has become a key tool in the modernization of the healthcare industry, aiding dentists in performing their work more efficiently and effectively. The aim of this study was to evaluate orthodontic monitoring and patient pe...
As technology advances, more AI entities are deployed in public service roles. However, AI service robot failures are increasingly frequent, causing negative behaviors such as customer dissatisfaction or complaints. Service recovery plays a crucial r...
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