MOTIVATION: Deep learning architectures have recently demonstrated their power in predicting DNA- and RNA-binding specificity. Existing methods fall into three classes: Some are based on convolutional neural networks (CNNs), others use recurrent neur...
As a data-driven science, genomics largely utilizes machine learning to capture dependencies in data and derive novel biological hypotheses. However, the ability to extract new insights from the exponentially increasing volume of genomics data requir...
Though the advent of long-read sequencing technologies has led to a leap in contiguity of de novo genome assemblies, current reference genomes of higher organisms still do not provide unbroken sequences of complete chromosomes. Despite reads in exces...
The current deluge of newly identified RNA transcripts presents a singular opportunity for improved assessment of coding potential, a cornerstone of genome annotation, and for machine-driven discovery of biological knowledge. While traditional, featu...
Sequencing by translocating DNA fragments through an array of nanopores is a rapidly maturing technology that offers faster and cheaper sequencing than other approaches. However, accurately deciphering the DNA sequence from the noisy and complex elec...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2018
Metagenomics is the study of microbial community diversity, especially the uncultured microorganisms by shotgun sequencing environmental samples. As the sequencers throughput and the data volume increase, it becomes challenging to develop scalable bi...
Water science and technology : a journal of the International Association on Water Pollution Research
Oct 1, 2017
Sudden diverging channels are one of the energy dissipaters which can dissipate most of the kinetic energy of the flow through a hydraulic jump. An accurate prediction of hydraulic jump characteristics is an important step in designing hydraulic stru...
Characterizing the binding behaviors of RNA-binding proteins (RBPs) is important for understanding their functional roles in gene expression regulation. However, current high-throughput experimental methods for identifying RBP targets, such as CLIP-s...