Global warming is becoming increasingly serious, with greenhouse gas (GHGs) emissions identified as a principal contributor. In response to the climate crisis, many countries are actively transitioning to renewable energy. Therefore, it is crucial to...
CPT: pharmacometrics & systems pharmacology
Nov 14, 2024
Age and aging are important predictors of health status, disease progression, drug kinetics, and effects. The purpose was to develop ensemble learning-based physiological age (PA) models for evaluating drug metabolism. National Health and Nutrition E...
In recent years, public health events have significantly impacted various aspects of human production and daily life, particularly in the domains of disease transmission and economic stability. While many scholars have primarily focused on the influe...
Technology and health care : official journal of the European Society for Engineering and Medicine
Nov 8, 2024
BackgroundPoorly regulated and insufficiently maintained medical devices (MDs) carry high risk on safety and performance parameters impacting the clinical effectiveness and efficiency of patient diagnosis and treatment. After the MD directive (MDD) h...
A polluted air environment can potentially provoke infections of diverse respiratory diseases. The development of mathematical models can study the mechanism of air pollution and its effect on the spread of diseases. The key is to characterize the in...
Although composting has many advantages in treating organic waste, many problems and challenges are still associated with emissions, like NH, CO and HS, as well as greenhouse gases such as CO. One promising approach to enhancing composting conditions...
Deep generative models are gaining attention in the field of de novo drug design. However, the rational design of ligand molecules for novel targets remains challenging, particularly in controlling the properties of the generated molecules. Here, ins...
Computational models that can predict growth and remodeling of the heart could have important clinical applications. However, the time it takes to calibrate and run current models while considering data uncertainty and variability makes them impracti...
Pharmacokinetic (PK) properties of a drug are vital attributes influencing its therapeutic effectiveness, playing an important role in the drug development process. Focusing on the difficult task of predicting PK parameters, we compiled an extensive ...
INTRODUCTION: The mortality rate among older people infected with severe acute respiratory syndrome coronavirus 2 is alarmingly high. This study aimed to explore the predictive value of a novel model for assessing the risk of death in this vulnerable...
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