AIMC Topic: Carbapenems

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Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Feb 12, 2020
OBJECTIVES: Increased rates of carbapenem-resistant strains of Acinetobacter baumannii have forced clinicians to rely upon last-line agents, such as the polymyxins, or empirical, unoptimized combination therapy. Therefore, the objectives of this stud...
Acinetobacter baumannii Carbapenems Meropenem Acinetobacter Infections Polymyxin B Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Drug Therapy, Combination Humans Machine Learning
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Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using supervised machine learning approach.

PloS one Feb 6, 2020
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a significant pathogen causing healthcare-associated infections. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight mass spectrometry (MALDI-TOF MS...
Carbapenem-Resistant Enterobacteriaceae Random Amplified Polymorphic DNA Technique Humans Algorithms Anti-Bacterial Agents Predictive Value of Tests Supervised Machine Learning Carbapenems Cross Infection Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization DNA, Bacterial Klebsiella Infections Microbial Sensitivity Tests Klebsiella pneumoniae
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Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii.

Journal of infection in developing countries Oct 31, 2019
INTRODUCTION: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The stu...
Microbial Sensitivity Tests Female Acinetobacter Infections Tertiary Care Centers Tigecycline Acinetobacter baumannii Humans Bacterial Proteins Drug Resistance, Microbial Male beta-Lactamases Anti-Bacterial Agents Carbapenems Colistin Pakistan
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Prediction of HPLC retention times of tebipenem pivoxyl and its degradation products in solid state by applying adaptive artificial neural network with recursive features elimination.

Talanta Feb 4, 2015
A sensitive and fast HPLC method using ultraviolet diode-array detector (DAD)/electrospray ionization tandem mass spectrometry (Q-TOF-MS/MS) was developed for the determination of tebipenem pivoxyl and in the presence of degradation products formed d...
Electrical Equipment and Supplies Tandem Mass Spectrometry Neural Networks, Computer Carbapenems Models, Chemical Time Factors Chromatography, High Pressure Liquid
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Rapid Identification and Typing of Carbapenem-Resistant Klebsiella pneumoniae Using MALDI-TOF MS and Machine Learning.

Microbial biotechnology Jun 1, 2025
Use matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) to screen the specific mass peaks of carbapenem-resistant Klebsiella pneumoniae (CRKP), compare the differences in spectrum peaks between intestinal and b...
Klebsiella pneumoniae Klebsiella Infections Machine Learning Sensitivity and Specificity Carbapenems Bacterial Typing Techniques Bacterial Proteins Carbapenem-Resistant Enterobacteriaceae Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Humans
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Precise Detection of Carbapenem-Resistant and Hypervirulent Using MOF-Derived Bimetallic Nanocube Hybrid Nanosheet.

Analytical chemistry May 13, 2025
Carbapenem resistance and hypervirulence represent two distinct evolutionary pathways in , posing significant challenges in clinical settings. Of particular concern are convergent strains that combine both traits, complicating timely diagnosis and tr...
Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Humans Nanostructures Metal Nanoparticles Klebsiella pneumoniae Carbapenems Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Metal-Organic Frameworks Klebsiella Infections
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