BACKGROUND: Tinidazole (TNZ) is an anti-parasite drug used in the treatment of a variety of amebic and parasitic infections. It has low solubility in aqueous media and is categorized under Class II of the Biopharmaceutical Classification System.
The guanine incropped Cu based metal-organic framework (Guanine-Cu-MOF) was synthesized by facile one-step sonochemical method by simply mixing of 4-4, biphenyldicarboxylic, guanine and copper nitrate (Bio-Cu-Hbpdc-Gu). The prepared guanine-MOF was c...
The evolution of the degradation by-products of an acetaminophen (ACE) solution was monitored by HPLC-UV/MS and IC in parallel with its ecotoxicity (Vibrio fischeri 81.9%, Microtox screening tests) during electro-Fenton (EF) oxidation performed on ca...
International journal of hygiene and environmental health
28063899
BACKGROUND: Perfluoroalkyl acids (PFAAs) are persistent and bioaccumulating compounds, which are spread all over the globe. We aimed to compare the PFAA concentrations in serum from pregnant women in five birth cohorts from four countries (Denmark, C...
European journal of nuclear medicine and molecular imaging
32556481
PURPOSE: To evaluate the performance of deep learning (DL) classifiers in discriminating normal and abnormal F-FACBC (fluciclovine, Axumin®) PET scans based on the presence of tumor recurrence and/or metastases in patients with prostate cancer (PC) a...
We introduce chemical reactivity flowcharts to help chemists interpret reaction outcomes using statistically robust machine learning models trained on a small number of reactions. We developed fast sulfonylimine multicomponent reactions for understan...
Physical chemistry chemical physics : PCCP
36134471
Efficient prediction of the partition coefficient (log ) between polar and non-polar phases could shorten the cycle of drug and materials design. In this work, a descriptor, named 〈 - ACSFs〉, is proposed to take the explicit polarization effects in t...
Journal of chemical information and modeling
39916507
Carbon dioxide (CO) can be transformed into valuable chemical building blocks, including C2-carboxylated 1,3-azoles, which have potential applications in pharmaceuticals, cosmetics, and pesticides. However, only a small fraction of the millions of av...