AIMC Topic: Complement System Proteins

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Urinary Complement proteome strongly linked to diabetic kidney disease progression.

Nature communications
Diabetic kidney disease (DKD) progression is not well understood. Using high-throughput proteomics, biostatistical, pathway and machine learning tools, we examine the urinary Complement proteome in two prospective cohorts with type 1 or 2 diabetes an...

Genetic prediction of ICU hospitalization and mortality in COVID-19 patients using artificial neural networks.

Journal of cellular and molecular medicine
There is an unmet need of models for early prediction of morbidity and mortality of Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes of ICU hospitalization and death,...