AIMC Topic: Computational Biology

Clear Filters Showing 1151 to 1160 of 4399 articles

Identification of shared potential diagnostic markers in asthma and depression through bioinformatics analysis and machine learning.

International immunopharmacology
BACKGROUND: There is mounting evidence that asthma might exacerbate depression. We sought to examine candidates for diagnostic genes in patients suffering from asthma and depression.

Emerging structure-based computational methods to screen the exploding accessible chemical space.

Current opinion in structural biology
Structure-based virtual screening can be a valuable approach to computationally select hit candidates based on their predicted interaction with a protein of interest. The recent explosion in the size of chemical libraries increases the chances of hit...

CRIECNN: Ensemble convolutional neural network and advanced feature extraction methods for the precise forecasting of circRNA-RBP binding sites.

Computers in biology and medicine
Circular RNAs (circRNAs) have surfaced as important non-coding RNA molecules in biology. Understanding interactions between circRNAs and RNA-binding proteins (RBPs) is crucial in circRNA research. Existing prediction models suffer from limited availa...

PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis.

Aging
BACKGROUND: Diabetic foot ulcers (DFUs) pose a serious long-term threat because of elevated mortality and disability risks. Research on its biomarkers is still, however, very limited. In this paper, we have effectively identified biomarkers linked wi...

DeepDynaForecast: Phylogenetic-informed graph deep learning for epidemic transmission dynamic prediction.

PLoS computational biology
In the midst of an outbreak or sustained epidemic, reliable prediction of transmission risks and patterns of spread is critical to inform public health programs. Projections of transmission growth or decline among specific risk groups can aid in opti...

Predicting lysine methylation sites using a convolutional neural network.

Methods (San Diego, Calif.)
Protein lysine methylation is a particular type of post translational modification that plays an important role in both histone and non-histone function regulation in proteins. Deregulation caused by lysine methyltransferases has been identified as t...

Stack-AAgP: Computational prediction and interpretation of anti-angiogenic peptides using a meta-learning framework.

Computers in biology and medicine
BACKGROUND: Angiogenesis plays a vital role in the pathogenesis of several human diseases, particularly in the case of solid tumors. In the realm of cancer treatment, recent investigations into peptides with anti-angiogenic properties have yielded en...

Prioritization of genes for translation: a computational approach.

Expert review of proteomics
INTRODUCTION: Gene identification for genetic diseases is critical for the development of new diagnostic approaches and personalized treatment options. Prioritization of gene translation is an important consideration in the molecular biology field, a...

Advancing Drug-Target Interaction prediction with BERT and subsequence embedding.

Computational biology and chemistry
Exploring the relationship between proteins and drugs plays a significant role in discovering new synthetic drugs. The Drug-Target Interaction (DTI) prediction is a fundamental task in the relationship between proteins and drugs. Unlike encoding prot...