The increasing prevalence of central nervous system (CNS) disorders has imposed a significant social and economic burden on healthcare systems. The blood-brain barrier (BBB) presents a major challenge for effective drug delivery to the brain, hinderi...
The ever-increasing availability of high-throughput DNA sequences and the development of numerous computational methods have led to considerable advances in our understanding of the evolutionary and demographic history of populations. Several demogra...
Artificial musculoskeletal systems mimic mammalian biomechanics using antagonistic muscles and rigid skeletons. They offer benefits such as adjustable stiffness, back-drivability, and muscle failure tolerance but are difficult to model and control du...
In this work, we study the nonlinear dynamics of tail motion using numerical simulations and experiments. Our simulations are based on a discrete model comprising rigid cylinders (representing vertebrae) coupled by longitudinal, shear, and bending sp...
The International journal of artificial organs
Jun 6, 2025
Ventricular assist devices (VADs) are essential for end-stage heart failure patients, but their design must balance hydraulic efficiency and hemocompatibility to minimize blood damage. This study presents a multi-objective optimization framework inte...
OBJECTIVE: As machine learning adoption in clinical practice continues to grow, deployed classifiers must be continuously monitored and updated (retrained) to protect against data drift that stems from inevitable changes, including evolving medical p...
Stick insects exhibit remarkable adaptive walking capabilities across diverse environments; however, the mechanisms underlying their gait transitions remain poorly understood. Although reinforcement learning (RL) has been employed to generate insect-...
In response to the urgent issues faced by current bionic undulating fin robot propulsion mechanisms, such as low working efficiency, insufficient swimming speed, ignoring thickness parameters, and the need for further improvement in biomimetic degree...
Biological systems maintain stability of their function in spite of external and internal perturbations. An important challenge in studying biological regulation is to identify the control objectives based on empirical data. Very often these objectiv...
Proceedings of the National Academy of Sciences of the United States of America
Jun 4, 2025
Characterizing the conformational ensemble of biomolecular systems is key to understand their functions. Cryoelectron microscopy (cryo-EM) captures two-dimensional snapshots of biomolecular ensembles, giving in principle access to thermodynamics. How...
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