Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Apr 26, 2021
Structured Illumination Microscopy (SIM) is a widespread methodology to image live and fixed biological structures smaller than the diffraction limits of conventional optical microscopy. Using recent advances in image up-scaling through deep learning...
Phosphine-borane complexes are novel chemical entities with preclinical efficacy in neuronal and ophthalmic disease models. In vitro and in vivo studies showed that the metabolites of these compounds are capable of cleaving disulfide bonds implicated...
Nonlinear dynamics of spiking neural networks have recently attracted much interest as an approach to understand possible information processing in the brain and apply it to artificial intelligence. Since information can be processed by collective sp...
Extended state observer acting as a popular tool can estimate the system states and total disturbances simultaneously. However, for extended-state-observer-based control of high-order nonlinear systems, there are still some difficult issues to solve,...
Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high affinity and specificity. They are typically discovered by searching large libraries for sequences with desirable binding properties. These libraries, however, ...
Neural networks : the official journal of the International Neural Network Society
Apr 21, 2021
This article is devoted to the H estimation problem for stochastic semi-Markovian switching complex-valued neural networks subject to incomplete measurement outputs, where the time-varying delay also depends on another semi-Markov process. A sequence...
Neural networks : the official journal of the International Neural Network Society
Apr 20, 2021
Numerical simulation of wildland fire spread is useful to predict the locations that are likely to burn and to support decision in an operational context, notably for crisis situations and long-term planning. For short-term, the computational time of...
Neural networks : the official journal of the International Neural Network Society
Apr 20, 2021
In this paper, the bipartite synchronization issue for a class of coupled reaction-diffusion networks with antagonistic interactions and switching topologies is investigated. First of all, by virtue of Lyapunov functional method and pinning control t...
We constructed machine learning-based pharmacokinetic prediction models with very high performance. The models were trained on 26138 and 16613 compounds involved in metabolic stability and cytochrome P450 inhibition, respectively. Because the compoun...
Clinical pharmacology and therapeutics
Apr 19, 2021
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for ...
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