AIMC Topic: Alveolar Epithelial Cells

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Novel AT2 Cell Subpopulations and Diagnostic Biomarkers in IPF: Integrating Machine Learning with Single-Cell Analysis.

International journal of molecular sciences Jul 15, 2024
Idiopathic pulmonary fibrosis (IPF) is a long-term condition with an unidentified cause, and currently there are no specific treatment options available. Alveolar epithelial type II cells (AT2) constitute a heterogeneous population crucial for secret...
Male Machine Learning Gene Expression Profiling Prognosis Female Biomarkers Humans Single-Cell Analysis Idiopathic Pulmonary Fibrosis Alveolar Epithelial Cells Transcriptome
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Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis.

Journal of environmental sciences (China) Jul 29, 2023
Epidemiological evidence presents that dust storms are related to respiratory diseases, such as pulmonary fibrosis (PF). However, the precise underlying mechanisms of SPM-elicited adverse effects still need to be investigated. Epithelial-mesenchymal ...
Transforming Growth Factor beta1 Interleukin-8 Smad3 Protein Alveolar Epithelial Cells Pulmonary Fibrosis Epithelial-Mesenchymal Transition Reactive Oxygen Species Particulate Matter Epithelial Cells Humans
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Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing.

Stem cells translational medicine Sep 22, 2020
Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we were not prepared. Several clinical trials using previously approved drugs and drug combinations are urgently under way to improve the current situation. A vaccine ...
Disease Outbreaks Genotype Drug Discovery COVID-19 Drug Treatment Drug Industry Alveolar Epithelial Cells Drug Repositioning Computer Simulation Lung SARS-CoV-2 Machine Learning Pandemics Humans Pluripotent Stem Cells Genome, Viral
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Rapid Communication: Prolactin and hydrocortisone impact TNFα-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells.

Journal of animal science Dec 1, 2017
The objective of this study was to evaluate the effects of the hormones prolactin (PRL) and hydrocortisone (HC) on bovine mammary alveolar (MAC-T) cells mitogen-activated protein kinase (MAPK) inflammatory signaling and inflammatory gene expression. ...
Inflammation Phosphorylation Signal Transduction Animals Cattle Tumor Necrosis Factor-alpha Female Cells, Cultured Prolactin JNK Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases Anti-Inflammatory Agents Hydrocortisone Mammary Glands, Animal Alveolar Epithelial Cells
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