AIMC Topic: Alveolar Epithelial Cells

Clear Filters Showing 1 to 5 of 5 articles

Single cell and machine learning identify type II pneumocyte-derived biomarkers HN1/OCIAD2/SFTA2 for non-small cell lung cancer prognosis and immune regulation.

European journal of medical research Nov 26, 2025
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the most prevalent malignancies and currently shows a poor clinical prognosis. Type II pneumocyte, as one of the main sources of cancer cells in NSCLC, is important to explore the molecular fun...
Transcriptome Single-Cell Analysis Biomarkers, Tumor Gene Expression Profiling Carcinoma, Non-Small-Cell Lung Alveolar Epithelial Cells Lung Neoplasms Gene Expression Regulation, Neoplastic Humans Machine Learning Prognosis
View on PubMed DOI

Novel AT2 Cell Subpopulations and Diagnostic Biomarkers in IPF: Integrating Machine Learning with Single-Cell Analysis.

International journal of molecular sciences Jul 15, 2024
Idiopathic pulmonary fibrosis (IPF) is a long-term condition with an unidentified cause, and currently there are no specific treatment options available. Alveolar epithelial type II cells (AT2) constitute a heterogeneous population crucial for secret...
Humans Machine Learning Female Male Biomarkers Prognosis Alveolar Epithelial Cells Single-Cell Analysis Gene Expression Profiling Idiopathic Pulmonary Fibrosis Transcriptome
View on PubMed DOI

Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis.

Journal of environmental sciences (China) Jul 29, 2023
Epidemiological evidence presents that dust storms are related to respiratory diseases, such as pulmonary fibrosis (PF). However, the precise underlying mechanisms of SPM-elicited adverse effects still need to be investigated. Epithelial-mesenchymal ...
Interleukin-8 Reactive Oxygen Species Humans Epithelial Cells Transforming Growth Factor beta1 Smad3 Protein Pulmonary Fibrosis Particulate Matter Alveolar Epithelial Cells Epithelial-Mesenchymal Transition
View on PubMed DOI

Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing.

Stem cells translational medicine Sep 22, 2020
Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we were not prepared. Several clinical trials using previously approved drugs and drug combinations are urgently under way to improve the current situation. A vaccine ...
Genome, Viral Pluripotent Stem Cells Drug Repositioning Alveolar Epithelial Cells COVID-19 Drug Treatment Drug Industry Pandemics Disease Outbreaks Computer Simulation Genotype SARS-CoV-2 Drug Discovery Lung Humans Machine Learning
View on PubMed DOI

Rapid Communication: Prolactin and hydrocortisone impact TNFα-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells.

Journal of animal science Dec 1, 2017
The objective of this study was to evaluate the effects of the hormones prolactin (PRL) and hydrocortisone (HC) on bovine mammary alveolar (MAC-T) cells mitogen-activated protein kinase (MAPK) inflammatory signaling and inflammatory gene expression. ...
Tumor Necrosis Factor-alpha Mitogen-Activated Protein Kinases Alveolar Epithelial Cells Animals Hydrocortisone Mammary Glands, Animal Inflammation Cattle Prolactin JNK Mitogen-Activated Protein Kinases Cells, Cultured Phosphorylation Signal Transduction Anti-Inflammatory Agents Female
View on PubMed DOI
Popular Topics
Recent Journals