AIMC Topic: Computer Simulation

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RRT-CS: A free-collision planner for capsule-like SCORBOT by iterated learning.

PloS one
In this study, we present an enhanced Rapidly-exploring Random Trees (RRT) algorithm integrated with a visual servoing technique for recognizing unknown environments. The robotic platform utilized is the SCORBOT-ER-VII, which consists of five links, ...

Inverse modeling, analysis and control of twin rotor aerodynamic systems with optimized artificial intelligent controllers.

PloS one
This paper suggests a novel optimal inverse Radial Basis Function (RBF) neural network model for the control of Twin Rotor Aerodynamic Systems (TRAS), such as Multi-Input-Multi-Output (MIMO) systems with high nonlinearity and coupling effects between...

Reported liver toxicity of food chemicals in rats extrapolated to humans using virtual human-to-rat hepatic concentration ratios generated by pharmacokinetic modeling with machine learning-derived parameters.

The Journal of toxicological sciences
Pharmacokinetic data are not generally available for evaluating the toxicological potential of food chemicals. A simplified physiologically based pharmacokinetic (PBPK) model has been established to evaluate internal exposures to chemicals in rats or...

Improved in Silico Identification of Protein-Protein Interactions Using Deep Learning Approach.

IET systems biology
Protein-protein interactions (PPIs) perform significant functions in many biological activities likewise gene regulation, metabolic pathways and signal transduction. The deregulation of PPIs may cause deadly diseases, such as cancer, autoimmune, pern...

Intelligent Control to Suppress Epileptic Seizures in the Amygdala: In Silico Investigation Using a Network of Izhikevich Neurons.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Closed-loop electricalstimulation of brain structures is one of the most promising techniques to suppress epileptic seizures in drug-resistant refractory patients who are also ineligible to ablative neurosurgery. In this work, an intelligent controll...

Machine Learning in Early Prediction of Metabolism of Drugs.

Methods in molecular biology (Clifton, N.J.)
Machine learning (ML) has increasingly been applied to predict properties of drugs. Particularly, metabolism can be predicted with ML methods, which can be exploited during drug discovery and development. The prediction of metabolism is a crucial bot...

Optimizing Neuroprotective Nano-structured Lipid Carriers for Transdermal Delivery through Artificial Neural Network.

Pharmaceutical nanotechnology
BACKGROUND: Dementia associated with Alzheimer's disease (AD) is a neurological disorder. AD is a progressive neurodegenerative condition that predominantly impacts the elderly population, although it can also manifest in younger people through the i...

[Optimization of centrifugal artificial heart pump blade parameters based on back propagation neural network and grey wolf optimization algorithm].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
The impeller, as a key component of artificial heart pumps, experiences high shear stress due to its rapid rotation, which may lead to hemolysis. To enhance the hemolytic performance of artificial heart pumps and identify the optimal combination of b...

How to build the virtual cell with artificial intelligence: Priorities and opportunities.

Cell
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIVC), a mult...

Large-scale prediction of biological activities with Active-IT system.

Biomeditsinskaia khimiia
Traditional testing methods in pharmaceutical development can be time-consuming and costly, but in silico evaluation tools can offer a solution. Our in-house Active-IT system, a Ligand-Based Virtual Screening (LBVS) tool, was developed to predict the...