AIMC Topic: Computer Simulation

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RoBoT: a robust Bayesian hypothesis testing method for basket trials.

Biostatistics (Oxford, England) Oct 13, 2021
A basket trial in oncology encompasses multiple "baskets" that simultaneously assess one treatment in multiple cancer types or subtypes. It is well-recognized that hierarchical modeling methods, which adaptively borrow strength across baskets, can im...
Humans Research Design Bayes Theorem Probability Medical Oncology Computer Simulation Robotics
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VIRTUAL CLINICAL TRIALS IN MEDICAL IMAGING SYSTEM EVALUATION AND OPTIMISATION.

Radiation protection dosimetry Oct 12, 2021
Virtual clinical trials (VCTs) can be used to evaluate and optimise medical imaging systems. VCTs are based on computer simulations of human anatomy, imaging modalities and image interpretation. OpenVCT is an open-source framework for conducting VCTs...
Radiographic Image Enhancement Humans Mammography Artificial Intelligence Female Breast Computer Simulation Breast Neoplasms
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External and Internal Validation of a Computer Assisted Diagnostic Model for Detecting Multi-Organ Mass Lesions in CT images.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih Sep 30, 2021
Objective We developed a universal lesion detector (ULDor) which showed good performance in in-lab experiments. The study aims to evaluate the performance and its ability to generalize in clinical setting via both external and internal validation. Me...
Neural Networks, Computer Computer Simulation Tomography, X-Ray Computed Computers
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[Research on Self-perception and Active Warning Model of Medical Equipment Operation and Maintenance Status Based on Machine Learning Algorithm].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation Sep 30, 2021
The panoramic perception of medical equipment operation and maintenance status is the basic guarantee for the implementation of smart medical care, the machine learning algorithm-based autonomous perception and active early warning model of medical e...
Algorithms Surgical Equipment Machine Learning Self Concept Computer Simulation
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Dynamic Modeling, Analysis, and Design Synthesis of a Reduced Complexity Quadruped with a Serpentine Robotic Tail.

Integrative and comparative biology Sep 8, 2021
Serpentine tail structures are widely observed in the animal kingdom and are thought to help animals to handle various motion tasks. Developing serpentine robotic tails and using them on legged robots has been an attractive idea for robotics. This ar...
Robotics Motion Tail Computer Simulation Animals
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DeepLINK: Deep learning inference using knockoffs with applications to genomics.

Proceedings of the National Academy of Sciences of the United States of America Sep 7, 2021
We propose a deep learning-based knockoffs inference framework, DeepLINK, that guarantees the false discovery rate (FDR) control in high-dimensional settings. DeepLINK is applicable to a broad class of covariate distributions described by the possibl...
Deep Learning Genomics Computational Biology Algorithms Computer Simulation Neural Networks, Computer
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Hyperbolic relational graph convolution networks plus: a simple but highly efficient QSAR-modeling method.

Briefings in bioinformatics Sep 2, 2021
Accurate predictions of druggability and bioactivities of compounds are desirable to reduce the high cost and time of drug discovery. After more than five decades of continuing developments, quantitative structure-activity relationship (QSAR) methods...
Drug Discovery Organic Chemicals Molecular Structure Models, Chemical Computational Biology Algorithms Computer Simulation Drug Design Neural Networks, Computer Quantitative Structure-Activity Relationship Artificial Intelligence Computer Graphics
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A transformer architecture based on BERT and 2D convolutional neural network to identify DNA enhancers from sequence information.

Briefings in bioinformatics Sep 2, 2021
Recently, language representation models have drawn a lot of attention in the natural language processing field due to their remarkable results. Among them, bidirectional encoder representations from transformers (BERT) has proven to be a simple, yet...
Transcription, Genetic Multilingualism Enhancer Elements, Genetic Data Accuracy Deep Learning Semantics Humans DNA Computational Biology Computer Simulation Models, Biological Sensitivity and Specificity Natural Language Processing
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Anticancer peptides prediction with deep representation learning features.

Briefings in bioinformatics Sep 2, 2021
Anticancer peptides constitute one of the most promising therapeutic agents for combating common human cancers. Using wet experiments to verify whether a peptide displays anticancer characteristics is time-consuming and costly. Hence, in this study, ...
Deep Learning Computational Biology Benchmarking Drug Discovery Antineoplastic Agents Amino Acid Sequence Humans Neural Networks, Computer Neoplasms Peptides Computer Simulation
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An end-to-end heterogeneous graph representation learning-based framework for drug-target interaction prediction.

Briefings in bioinformatics Sep 2, 2021
Accurately identifying potential drug-target interactions (DTIs) is a key step in drug discovery. Although many related experimental studies have been carried out for identifying DTIs in the past few decades, the biological experiment-based DTI ident...
Machine Learning Software Computer Simulation Humans Proteins Drug Discovery Pharmaceutical Preparations Drug Development Drug-Related Side Effects and Adverse Reactions
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