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In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy.

Scientific reports
Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat ...

Finite element models with automatic computed tomography bone segmentation for failure load computation.

Scientific reports
Bone segmentation is an important step to perform biomechanical failure load simulations on in-vivo CT data of patients with bone metastasis, as it is a mandatory operation to obtain meshes needed for numerical simulations. Segmentation can be a tedi...

A novel fractional-order memristive Hopfield neural network for traveling salesman problem and its FPGA implementation.

Neural networks : the official journal of the International Neural Network Society
This paper proposes a novel fractional-order memristive Hopfield neural network (HNN) to address traveling salesman problem (TSP). Fractional-order memristive HNN can efficiently converge to a globally optimal solution, while conventional HNN tends t...

Leading-edge curvature effect on aerodynamic performance of flapping wings in hover and forward flight.

Bioinspiration & biomimetics
This study investigates the role of leading-edge (LE) curvature in flapping wing aerodynamics considering hovering and forward flight conditions. A scaled-up robotic model is towed along its longitudinal axis by a rack gear carriage system. The forwa...

Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via innovation.

Zeitschrift fur Naturforschung. C, Journal of biosciences
A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and...

Lag projective synchronization of discrete-time fractional-order quaternion-valued neural networks with time delays.

Neural networks : the official journal of the International Neural Network Society
This paper deals with the lag projective synchronization (LPS) problem for a class of discrete-time fractional-order quaternion-valued neural networks(DTFO QVNNs) systems with time delays. Firstly, a DTFOQVNNs system with time delay is constructed. S...

A collaborative neurodynamic approach with two-timescale projection neural networks designed via majorization-minimization for global optimization and distributed global optimization.

Neural networks : the official journal of the International Neural Network Society
In this paper, two two-timescale projection neural networks are proposed based on the majorization-minimization principle for nonconvex optimization and distributed nonconvex optimization. They are proved to be globally convergent to Karush-Kuhn-Tuck...

Improved switching condition for reachable set estimation of discrete-time switched delayed neural networks.

Neural networks : the official journal of the International Neural Network Society
This research delves into the reachable set estimation (RSE) problem for general switched delayed neural networks (SDNNs) in the discrete-time context. Note that existing relevant research on SDNNs predominantly relies on either time-dependent or sta...

Antiferromagnetic artificial neuron modeling of the withdrawal reflex.

Journal of computational neuroscience
Replicating neural responses observed in biological systems using artificial neural networks holds significant promise in the fields of medicine and engineering. In this study, we employ ultra-fast artificial neurons based on antiferromagnetic (AFM) ...

Artificial neural networks trained on simulated multispectral data for real-time imaging of skin microcirculatory blood oxygen saturation.

Journal of biomedical optics
SIGNIFICANCE: Imaging blood oxygen saturation ( ) in the skin can be of clinical value when studying ischemic tissue. Emerging multispectral snapshot cameras enable real-time imaging but are limited by slow analysis when using inverse Monte Carlo (M...