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COVID-19

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A SAR and QSAR study on 3CLpro inhibitors of SARS-CoV-2 using machine learning methods.

SAR and QSAR in environmental research
The 3C-like Proteinase (3CLpro) of novel coronaviruses is intricately linked to viral replication, making it a crucial target for antiviral agents. In this study, we employed two fingerprint descriptors (ECFP_4 and MACCS) to comprehensively character...

Shape prior-constrained deep learning network for medical image segmentation.

Computers in biology and medicine
We propose a shape prior representation-constrained multi-scale features fusion segmentation network for medical image segmentation, including training and testing stages. The novelty of our training framework lies in two modules comprised of the sha...

Testing behaviour change with an artificial intelligence chatbot in a randomized controlled study.

Journal of public health policy
Chatbots can effect large-scale behaviour change because they are accessible through social media, flexible, scalable, and gather data automatically. Yet research on the feasibility and effectiveness of chatbot-administered behaviour change intervent...

Adopting machine learning to predict ICU delirium.

Neurosurgical review
With neuropsychiatric complications recognized among COVID-19 patients translating into significant morbidity, we explore the current state-of-the-art for auto Machine Learning (ML) to predict ICU delirium among severe COVID-19 patients which has bee...

AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery.

Nature communications
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types. In this ...

COVID-19 prevention and control effect of non-pharmaceutical interventions-fuzzy-sets qualitative comparative analysis based on 69 countries in the world.

Frontiers in public health
INTRODUCTION: Coronavirus disease 2019 occurred unexpectedly in late December 2019, it was difficult to immediately develop an effective vaccine or propose targeted medical interventions in the early stages of the outbreak. At this point, non-pharmac...

HDConv: Heterogeneous kernel-based dilated convolutions.

Neural networks : the official journal of the International Neural Network Society
Dilated convolution has been widely used in various computer vision tasks due to its ability to expand the receptive field while maintaining the resolution of feature maps. However, the critical challenge is the gridding problem caused by the isomorp...

AI Hesitancy and Acceptability-Perceptions of AI Chatbots for Chronic Health Management and Long COVID Support: Survey Study.

JMIR human factors
BACKGROUND: Artificial intelligence (AI) chatbots have the potential to assist individuals with chronic health conditions by providing tailored information, monitoring symptoms, and offering mental health support. Despite their potential benefits, re...

Deep representation learning from electronic medical records identifies distinct symptom based subtypes and progression patterns for COVID-19 prognosis.

International journal of medical informatics
OBJECTIVE: Symptoms are significant kind of phenotypes for managing and controlling of the burst of acute infectious diseases, such as COVID-19. Although patterns of symptom clusters and time series have been considered the high potential prediction ...