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Optimization of metronidazole SR buccal tablet for gingivitis using genetic algorithm.

Pakistan journal of pharmaceutical sciences
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal table...

A Combination of Deep Neural Networks and Physics to Solve the Inverse Problem of Burger's Equation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
One of the most basic nonlinear Partial Differential Equations (PDEs) to model the effects of propagation and diffusion is Burger's equation. This puts great emphasize on seeking efficient versatile methods for finding a solution to the forward and i...

Finite-time stability and optimal control of an impulsive stochastic reaction-diffusion vegetation-water system driven by Lévy process with time-varying delay.

Mathematical biosciences and engineering : MBE
In this paper, a reaction-diffusion vegetation-water system with time-varying delay, impulse and Lévy jump is proposed. The existence and uniqueness of the positive solution are proved. Meanwhile, mainly through the principle of comparison, we obtain...

Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion.

Proceedings of the National Academy of Sciences of the United States of America
Single-particle tracking (SPT) is a key tool for quantitative analysis of dynamic biological processes and has provided unprecedented insights into a wide range of systems such as receptor localization, enzyme propulsion, bacteria motility, and drug ...

Classification of particle trajectories in living cells: Machine learning versus statistical testing hypothesis for fractional anomalous diffusion.

Physical review. E
Single-particle tracking (SPT) has become a popular tool to study the intracellular transport of molecules in living cells. Inferring the character of their dynamics is important, because it determines the organization and functions of the cells. For...

Deep reinforcement learning based valve scheduling for pollution isolation in water distribution network.

Mathematical biosciences and engineering : MBE
Public water supply facilities are vulnerable to intentional intrusion. In particular, Water Distribution Network (WDN) has become one of the most important public facilities that are prone to be attacked because of its wide coverage and constant ope...

Lyapunov functional for virus infection model with diffusion and state-dependent delays.

Mathematical biosciences and engineering : MBE
In this paper, a virus dynamics model with diffusion, state-dependent delays and a general nonlinear functional response is investigated. At first, the dynamical system is constructed on a nonlinear metric space. Then the stability of the interior eq...

Blood Brain Barrier Permeability Prediction Using Machine Learning Techniques: An Update.

Current pharmaceutical biotechnology
Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and e...

Engineering reaction-diffusion networks with properties of neural tissue.

Lab on a chip
We present an experimental system of networks of coupled non-linear chemical reactors, which we theoretically model within a reaction-diffusion framework. The networks consist of patterned arrays of diffusively coupled nanoliter-scale reactors contai...

Dynamics of coupled mode solitons in bursting neural networks.

Physical review. E
Using an electrically coupled chain of Hindmarsh-Rose neural models, we analytically derived the nonlinearly coupled complex Ginzburg-Landau equations. This is realized by superimposing the lower and upper cutoff modes of wave propagation and by empl...