AIMC Topic: DNA Modification Methylases

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DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.

Biosensors & bioelectronics Dec 29, 2015
DNA methyltransferase (MTase) has received a large amount of attention due to its catalyzation of DNA methylation in both eukaryotes and prokaryotes, which has a close relationship to cancer and bacterial diseases. Herein, a novel electrochemical str...
Humans Biosensing Techniques DNA Methylation Gold Metal Nanoparticles DNA Modification Methylases Adenine
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A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.

Scientific reports May 8, 2025
Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and ...
Humans Machine Learning Brain Neoplasms Cell Line, Tumor Cell Proliferation Cell Movement Glioblastoma DNA Modification Methylases DNA Repair Enzymes Drug Resistance, Neoplasm Tumor Suppressor Proteins Cell Cycle Temozolomide Antineoplastic Agents, Alkylating
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MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Jan 1, 2018
Glioblastoma Multiforme (GBM), a malignant brain tumor, is among the most lethal of all cancers. Temozolomide is the primary chemotherapy treatment for patients diagnosed with GBM. The methylation status of the promoter or the enhancer regions of the...
Humans Neural Networks, Computer Brain Neoplasms Computational Biology Databases, Genetic Magnetic Resonance Imaging DNA Methylation Glioblastoma Dacarbazine DNA Modification Methylases DNA Repair Enzymes Drug Resistance, Neoplasm Tumor Suppressor Proteins Temozolomide Antineoplastic Agents, Alkylating Regulatory Sequences, Nucleic Acid
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