AIMC Topic: DNA Modification Methylases
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Learning MRI-based classification models for MGMT methylation status prediction in glioblastoma.
Computer methods and programs in biomedicine
Dec 30, 2016
BACKGROUND AND OBJECTIVE: The O-methylguanine-DNA-methyltransferase (MGMT) promoter methylation has been shown to be associated with improved outcomes in patients with glioblastoma (GBM) and may be a predictive marker of sensitivity to chemotherapy. ...
Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence.
Analytica chimica acta
Dec 27, 2016
The analysis of DNA methylation and MTase activities is very important in the early clinical diagnosis of cancer, on purposes of providing insights into the mechanism of gene repression and developing novel drugs of treating methylation-related disea...
DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.
Biosensors & bioelectronics
Dec 29, 2015
DNA methyltransferase (MTase) has received a large amount of attention due to its catalyzation of DNA methylation in both eukaryotes and prokaryotes, which has a close relationship to cancer and bacterial diseases. Herein, a novel electrochemical str...
A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.
Scientific reports
May 8, 2025
Most cancers are genetically and phenotypically heterogeneous. This includes subpopulations of cells with different levels of sensitivity to chemotherapy, which may lead to treatment failure as the more resistant cells can survive drug treatment and ...
MRI to MGMT: predicting methylation status in glioblastoma patients using convolutional recurrent neural networks.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2018
Glioblastoma Multiforme (GBM), a malignant brain tumor, is among the most lethal of all cancers. Temozolomide is the primary chemotherapy treatment for patients diagnosed with GBM. The methylation status of the promoter or the enhancer regions of the...
DNA Repair Enzymes
Drug Resistance, Neoplasm
Databases, Genetic
Dacarbazine
Brain Neoplasms
DNA Methylation
Humans
Magnetic Resonance Imaging
Antineoplastic Agents, Alkylating
DNA Modification Methylases
Computational Biology
Glioblastoma
Neural Networks, Computer
Regulatory Sequences, Nucleic Acid
Tumor Suppressor Proteins
Temozolomide
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