AIMC Topic: DNA

Clear Filters Showing 91 to 100 of 457 articles

DRBpred: A sequence-based machine learning method to effectively predict DNA- and RNA-binding residues.

Computers in biology and medicine Jan 29, 2024
DNA-binding and RNA-binding proteins are essential to an organism's normal life cycle. These proteins have diverse functions in various biological processes. DNA-binding proteins are crucial for DNA replication, transcription, repair, packaging, and ...
Amino Acids DNA-Binding Proteins RNA Databases, Protein DNA Machine Learning Computational Biology RNA-Binding Proteins Algorithms
View on PubMed DOI

Mesophilic Argonaute-Mediated Polydisperse Droplet Biosensor for Amplification-Free, One-Pot, and Multiplexed Nucleic Acid Detection Using Deep Learning.

Analytical chemistry Jan 23, 2024
Detection of nucleic acids from a single multiplexed and amplification-free test is critical for ensuring food safety, clinical diagnostics, and environmental monitoring. In this study, we introduced a mesophilic Argonaute protein from (CbAgo), whic...
Nucleic Acid Amplification Techniques DNA Nucleic Acids Deep Learning Biosensing Techniques Argonaute Proteins
View on PubMed DOI

DARDN: A Deep-Learning Approach for CTCF Binding Sequence Classification and Oncogenic Regulatory Feature Discovery.

Genes Jan 23, 2024
Characterization of gene regulatory mechanisms in cancer is a key task in cancer genomics. CCCTC-binding factor (CTCF), a DNA binding protein, exhibits specific binding patterns in the genome of cancer cells and has a non-canonical function to facili...
CCCTC-Binding Factor DNA Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Deep Learning Transcription Factors Humans
View on PubMed DOI

DBPboost:A method of classification of DNA-binding proteins based on improved differential evolution algorithm and feature extraction.

Methods (San Diego, Calif.) Jan 17, 2024
DNA-binding proteins are a class of proteins that can interact with DNA molecules through physical and chemical interactions. Their main functions include regulating gene expression, maintaining chromosome structure and stability, and more. DNA-bindi...
DNA DNA-Binding Proteins Computational Biology Support Vector Machine Algorithms
View on PubMed DOI

Pattern recognition in the nucleation kinetics of non-equilibrium self-assembly.

Nature Jan 17, 2024
Inspired by biology's most sophisticated computer, the brain, neural networks constitute a profound reformulation of computational principles. Analogous high-dimensional, highly interconnected computational architectures also arise within information...
Microscopy, Atomic Force Pattern Recognition, Automated Microscopy, Fluorescence Kinetics Computer Simulation DNA Neural Networks, Computer
View on PubMed DOI

DNA Robots for CRISPR/Cas12a Activity Management and Universal Platforms for Biosensing.

Analytical chemistry Jan 13, 2024
The CRISPR/Cas12a system is a revolutionary genome editing technique that is widely employed in biosensing and molecular diagnostics. However, there are few reports on precisely managing the -cleavage activity of Cas12a by simple modification since t...
Colorimetry DNA CRISPR-Cas Systems Excision Repair Biosensing Techniques Robotics
View on PubMed DOI

Prevalence of JC Polyomavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia.

Medicina (Kaunas, Lithuania) Dec 29, 2023
: John Cunningham polyomavirus (JCPyV) is a highly prevalent virus in the human population. The prevalence of JCPyV in patients with central nervous system disorders has not been examined extensively. The aim of this study was to analyze the prevalen...
Headache Meningitis Seroepidemiologic Studies Humans Fever Male Immunoglobulin G JC Virus Prevalence Female Croatia DNA Aged
View on PubMed DOI

1,3,4-oxadiazole derivatives: synthesis, characterization, antifungal activity, DNA binding investigations, TD-DFT calculations, and molecular modelling.

Journal of biomolecular structure & dynamics Dec 21, 2023
1,3,4-Oxadiazole-based heterocyclic analogs (3a-3m) were synthesized cyclization of Schiff bases with substituted aldehydes in the presence of bromine and acetic acid. The structural clarification of synthesized molecules was carried out with variou...
Structure-Activity Relationship Models, Molecular Antifungal Agents Molecular Structure Oxadiazoles DNA Microbial Sensitivity Tests Humans Density Functional Theory Antioxidants Molecular Docking Simulation
View on PubMed DOI

Evaluation of DNA-protein complex structures using the deep learning method.

Physical chemistry chemical physics : PCCP Dec 21, 2023
Biological processes such as transcription, repair, and regulation require interactions between DNA and proteins. To unravel their functions, it is imperative to determine the high-resolution structures of DNA-protein complexes. However, experimental...
Deep Learning Protein Binding DNA Proteins Neural Networks, Computer Research Design
View on PubMed DOI

Hold out the genome: a roadmap to solving the cis-regulatory code.

Nature Dec 13, 2023
Gene expression is regulated by transcription factors that work together to read cis-regulatory DNA sequences. The 'cis-regulatory code' - how cells interpret DNA sequences to determine when, where and how much genes should be expressed - has proven ...
Genomics Models, Genetic Machine Learning Regulatory Sequences, Nucleic Acid Transcription Factors DNA
View on PubMed DOI
Popular Topics
Recent Journals