AIMC Topic: Cryptococcus neoformans

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Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans.

PLoS biology May 22, 2025
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fungal pathog...
Drug Resistance, Fungal Fungal Proteins Cryptococcosis Antifungal Agents Fluconazole Genome, Fungal DNA Transposable Elements Mutagenesis, Insertional Genes, Fungal Cryptococcus neoformans Humans Genes, Essential
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Does infection alter antifungal distribution: an animal model exploring pharmacokinetic changes.

Future microbiology Apr 3, 2025
AIM: Assessing the disseminated meningitis caused by in Wistar rats and its impact on antifungal distribution by microdialysis (µD).
Microdialysis Meningitis, Cryptococcal Cryptococcus neoformans Rats Disease Models, Animal Fluconazole Cryptococcosis Antifungal Agents Male Brain Rats, Wistar Animals
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Combining natural language processing and metabarcoding to reveal pathogen-environment associations.

PLoS neglected tropical diseases Apr 7, 2021
Cryptococcus neoformans is responsible for life-threatening infections that primarily affect immunocompromised individuals and has an estimated worldwide burden of 220,000 new cases each year-with 180,000 resulting deaths-mostly in sub-Saharan Africa...
Machine Learning Ecosystem Models, Theoretical Humans RNA, Ribosomal, 18S Cryptococcus neoformans Trees Environmental Microbiology Metagenomics Soil Microbiology Natural Language Processing
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Gene Essentiality Analyzed by Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of .

mBio Oct 30, 2018
Knowing the full set of essential genes for a given organism provides important information about ways to promote, and to limit, its growth and survival. For many non-model organisms, the lack of a stable haploid state and low transformation efficien...
Genetics, Microbial Histoplasma Haploidy DNA Transposable Elements Mutagenesis, Insertional Candida albicans Genes, Essential Genes, Fungal Cryptococcus neoformans Aspergillus fumigatus Machine Learning
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Desert actinobacteria as a source of bioactive compounds production with a special emphases on Pyridine-2,5-diacetamide a new pyridine alkaloid produced by Streptomyces sp. DA3-7.

Microbiological research Nov 21, 2017
In the present study, 134 morphologically distinct actinobacteria isolates were obtained from soil samples from 10 different localities in the Saudi Arabian desert. The preliminary screening revealed that 16 of these isolates possessed antimicrobial ...
Streptomyces Soil Microbiology Adenocarcinoma Escherichia coli Breast Neoplasms MCF-7 Cells Female Cryptococcus neoformans Antineoplastic Agents Microbial Sensitivity Tests Desert Climate Saudi Arabia Enterococcus faecalis Humans Salmonella typhimurium Cell Line, Tumor Anti-Infective Agents Pyridines Alkaloids
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In Vitro Antifungal Susceptibility of Environmental Isolates of spp. from the West Region of Cameroon.

Ethiopian journal of health sciences Nov 1, 2016
BACKGROUND: Cryptococcus neoformans is responsible of cryptococcosis, a life-threatening infection that affects healthy and immunocompromised individuals. It is the first cause of adult acute meningitis in some sub-Saharan African countries with a mo...
Feces Antifungal Agents Chiroptera Columbidae Cryptococcus neoformans Microbial Sensitivity Tests Cameroon Animals
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