AIMC Topic: Estrogen Antagonists

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MATH: A Deep Learning Approach in QSAR for Estrogen Receptor Alpha Inhibitors.

Molecules (Basel, Switzerland) Aug 3, 2023
Breast cancer ranks as the second leading cause of death among women, but early screening and self-awareness can help prevent it. Hormone therapy drugs that target estrogen levels offer potential treatments. However, conventional drug discovery entai...
Humans Female Breast Neoplasms Deep Learning Estrogens Estrogen Antagonists Quantitative Structure-Activity Relationship Estrogen Receptor alpha
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BPA, BADGE and analogues: A new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties.

Chemosphere Dec 28, 2018
Information on the occurrence and endocrine potencies of analogues of bisphenol A (BPA) and diglycidyl ester derivatives (BDGEs) of BPA and BPF is limited. Such information is, however, important as the current debate on BPA and the lowered BPA migra...
Food Contamination Europe Chromatography, Liquid Phenols Androgen Antagonists Tandem Mass Spectrometry Esters Benzhydryl Compounds Estrogen Antagonists
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Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Humans Female Young Adult Adult Male Oxidative Stress Estradiol Antioxidants Plant Extracts Dose-Response Relationship, Drug Reactive Oxygen Species Plant Leaves Oxidation-Reduction DNA Damage Drug Evaluation, Preclinical Olea Blood Cells Comet Assay Diethylstilbestrol Estrogen Antagonists Free Radical Scavengers
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