AIMC Topic: Fluorine Radioisotopes

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Automated electrophilic radiosynthesis of [¹⁸F]FBPA using a modified nucleophilic GE TRACERlab FXFDG.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
We modified a commercially available synthesis module for nucleophilic [(18)F]fluorinations (TRACERlab(TM) FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[(18)F]fluoro-4-borono-L-phenylalanine ([(18)F]FBPA) via direct electrophilic subst...

Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to...

Automated radiosynthesis of [(18)F]ciprofloxacin.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing th...

Advances in the application of 18 F-sodium fluoride PET in the assessment of atherosclerosis.

Nuclear medicine communications
Atherosclerosis serves as the primary cause of cardiovascular diseases (CVDs), with its pathological processes encompassing lipid deposition, inflammatory responses, and calcification. Traditional imaging techniques, such as computed tomography angio...

Evaluating Automated Tools for Lesion Detection on F Fluoroestradiol PET/CT Images and Assessment of Concordance with Standard-of-Care Imaging in Metastatic Breast Cancer.

Radiology. Imaging cancer
Purpose To evaluate two automated tools for detecting lesions on fluorine 18 (F) fluoroestradiol (FES) PET/CT images and assess concordance of F-FES PET/CT with standard diagnostic CT and/or F fluorodeoxyglucose (FDG) PET/CT in patients with breast c...

Potential Applications of Artificial Intelligence and Machine Learning in Radiochemistry and Radiochemical Engineering.

PET clinics
Artificial intelligence and machine learning are poised to disrupt PET imaging from bench to clinic. In this perspective, the authors offer insights into how the technology could be applied to improve the radiosynthesis of new radiopharmaceuticals fo...