AIMC Topic: Telomere
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Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.
Frontiers in immunology
May 22, 2025
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.
A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health.
International journal of environmental research and public health
Dec 19, 2024
BACKGROUND: Gastrointestinal (GI) distress is prevalent and often persistent among cancer survivors, impacting their quality of life, nutrition, daily function, and mortality. GI health screening is crucial for preventing and managing this distress. ...
Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers.
Scientific reports
Dec 5, 2024
This retrospective study explored the association between circulating cell-free plasma telomere length (cf-TL) and coronary artery disease (CAD) and heart failure (HF). Data from 518 participants were collected, including clinical and laboratory data...
Association of retinal image-based, deep learning cardiac BioAge with telomere length and cardiovascular biomarkers.
Optometry and vision science : official publication of the American Academy of Optometry
Jun 28, 2024
SIGNIFICANCE: Our retinal image-based deep learning (DL) cardiac biological age (BioAge) model could facilitate fast, accurate, noninvasive screening for cardiovascular disease (CVD) in novel community settings and thus improve outcome with those wit...
Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.
Nature communications
Jun 18, 2024
Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy. Here, we deploy digital telomere measurement (DTM) by nanopore sequencing to un...
On Minimizers and Convolutional Filters: Theoretical Connections and Applications to Genome Analysis.
Journal of computational biology : a journal of computational molecular cell biology
Apr 30, 2024
Insights into the Kinetic Partitioning Folding Dynamics of the Human Telomeric G-Quadruplex from Molecular Simulations and Machine Learning.
Journal of chemical theory and computation
Aug 25, 2020
The human telomeric DNA G-quadruplex follows a kinetic partitioning folding mechanism. The underlying folding landscape potentially has many minima separated by high free-energy barriers. However, using current theoretical models to characterize this...
DeepSTORM3D: dense 3D localization microscopy and PSF design by deep learning.
Nature methods
Jun 15, 2020
An outstanding challenge in single-molecule localization microscopy is the accurate and precise localization of individual point emitters in three dimensions in densely labeled samples. One established approach for three-dimensional single-molecule l...
Identification of a telomere-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization.
Medicine
Apr 18, 2025
Telomere-related genes (TRGs) are vital in diverse tumor types. Nevertheless, there is a notable lack of in-depth research concerning their significance in head and neck squamous cell carcinoma (HNSCC). In this context, the present study aims to asse...
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