Analytical methods : advancing methods and applications
Sep 25, 2025
Simultaneous monitoring of catecholamine neurotransmitters (CNTs)-including epinephrine (Epi), norepinephrine (NE), levodopa (L-DOPA), and dopamine (DA)-is essential for the accurate diagnosis and effective management of various neurological disorder...
Exosomes are critical biomarkers for early cancer diagnosis and prognosis due to their rich biological information. Nevertheless, analyzing exosomal biomarkers comprehensively remains challenging. Surface-enhanced Raman scattering (SERS) has been emp...
Detecting single point mutations, such as PIK3CA mutations, is vital for precision diagnostics but remains challenging due to subtle sequence differences. This study introduces a machine learning-assisted colorimetric biosensor that utilizes DNA-temp...
Surface-enhanced Raman spectroscopy (SERS) has shown potential for early disease diagnosis via urinary metabolomics, but still faces challenges in achieving stable hot spots and processing complex clinical data. In this study, the preparation of chir...
Nitrogen-vacancy (NV) centers in diamond demonstrate advantages in biosensing due to their exceptional photostability and long spin coherence time. However, clinical applications of NV centers are significantly limited because their spin states lack ...
Extracellular vesicles (EVs) have emerged as promising biomarkers in cancer diagnostics. However, rapid and nondestructive isolation of EVs from plasma remains challenging due to the presence of abundant interferents with smaller sizes (e.g., protein...
Whole-cell biosensors (WCBs), which detect targeting analytes through cellular responses, have become powerful tools for environmental monitoring. However, existing WCBs often rely on the single-channel low-dimension signal outputs (e.g., fluorescenc...
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
Point-of-care (POC) devices have grown in popularity due to their ease of use, low cost, and speedy on-site diagnostic capabilities. This study focuses on ketamine detection by colorimetric and lateral flow assays (LFA), with aptamer-based LFA emergi...
A non-invasive, enzyme-based colorimetric biosensor was developed for urea detection in saliva, utilizing a growth-based method with Au@Ag core-shell nanostructures, including CTAB-coated gold nanoparticles (AuNPs) and CTAB-coated gold nanorods with ...
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