AIMC Topic: Gram-Negative Bacteria

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Accurate prediction of multi-label protein subcellular localization through multi-view feature learning with RBRL classifier.

Briefings in bioinformatics Sep 2, 2021
Multi-label proteins can participate in carrier transportation, enzyme catalysis, hormone regulation and other life activities. Meanwhile, they play a key role in the fields of biopharmaceuticals, gene and cell therapy. This article proposes a predic...
Amino Acid Sequence Data Accuracy Computational Biology Amino Acids Support Vector Machine Plants Databases, Protein Viruses Discriminant Analysis Intracellular Space Proteins Gram-Negative Bacteria Position-Specific Scoring Matrices Gene Ontology
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DeepT3: deep convolutional neural networks accurately identify Gram-negative bacterial type III secreted effectors using the N-terminal sequence.

Bioinformatics (Oxford, England) Jun 1, 2019
MOTIVATION: Various bacterial pathogens can deliver their secreted substrates also called effectors through Type III secretion systems (T3SSs) into host cells and cause diseases. Since T3SS secreted effectors (T3SEs) play important roles in pathogen-...
Algorithms Bacterial Proteins Neural Networks, Computer Software Gram-Negative Bacteria Genome, Bacterial
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Bastion3: a two-layer ensemble predictor of type III secreted effectors.

Bioinformatics (Oxford, England) Jun 1, 2019
MOTIVATION: Type III secreted effectors (T3SEs) can be injected into host cell cytoplasm via type III secretion systems (T3SSs) to modulate interactions between Gram-negative bacterial pathogens and their hosts. Due to their relevance in pathogen-hos...
Machine Learning Software Algorithms Computational Biology Bacterial Proteins Amino Acid Sequence Gram-Negative Bacteria
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Improving Recognition of Antimicrobial Peptides and Target Selectivity through Machine Learning and Genetic Programming.

IEEE/ACM transactions on computational biology and bioinformatics Jan 1, 2017
Growing bacterial resistance to antibiotics is spurring research on utilizing naturally-occurring antimicrobial peptides (AMPs) as templates for novel drug design. While experimentalists mainly focus on systematic point mutations to measure the effec...
Antimicrobial Cationic Peptides Gram-Negative Bacteria Gram-Positive Bacteria Genetic Engineering Computational Biology Decision Trees Algorithms Drug Design Neural Networks, Computer Machine Learning
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[Synthesis and biological evaluation of novel pleuromutilin derivatives with nitrogen-containing heterocycles as antibacterial agents].

Yao xue xue bao = Acta pharmaceutica Sinica Oct 1, 2015
A series of new pleuromutilins derivatives were designed and synthesized through coupling 2-aminothiazole ring of WL001 with different nitrogen-containing substituted heterocycles in the side chain. Their biological activities were evaluated against ...
Nitrogen Structure-Activity Relationship Polycyclic Compounds Gram-Negative Bacteria Pleuromutilins Amoxicillin Anti-Bacterial Agents Diterpenes Microbial Sensitivity Tests Levofloxacin
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Antimicrobial activity of complete denture cleanser solutions based on sodium hypochlorite and Ricinus communis - a randomized clinical study.

Journal of applied oral science : revista FOB Jan 1, 2015
UNLABELLED: To preserve oral health and to maintain the prosthetic devices, it is important not only to improve the properties of commonly known hygiene products, but also to investigate new materials with antimicrobial action. Objectives This study ...
Humans Female Biofilms Time Factors Ricinus Candida Aged Anti-Infective Agents, Local Male Sodium Hypochlorite Denture Cleansers Streptococcus mutans Statistics, Nonparametric Gram-Negative Bacteria Castor Oil Denture, Complete Colony Count, Microbial
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Nemonoxacin has potent activity against gram-positive, but not gram-negative clinical isolates.

La Clinica terapeutica Jan 1, 2015
OBJECTIVES: The aim of the current study was to analyze the susceptibility of gram-positive and -negative clinical isolates to a novel des-F(6)-quinolone (nemonoxacin) and other selected antimicrobial agents.
Quinolones Anti-Bacterial Agents Gram-Negative Bacteria Microbial Sensitivity Tests Gram-Positive Bacteria
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